876150-14-0
Chemical Structure
Octyl-α-ketoglutarate
Synonym(s): 1-Octyl 2-oxopentanedioate
- CAS No.: 876150-14-0
- Formula:C13H22O5
- Molecular Weight:258.31
IUPAC Name: 5-(octyloxy)-4,5-dioxopentanoic acid
InChIKey: QNFIHKFBQFJVKV-UHFFFAOYSA-N
SMILES: O=C(OCCCCCCCC)C(CCC(O)=O)=O
Biological Activity: Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD[1].
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Octyl-α-ketoglutarate | 99.9% | Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD. | ||||||||||||||||||||
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Keywords
