2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. Oxalomalic acid trisodium

Oxalomalic acid trisodium  (Synonyms: Oxalomalate trisodium)

製品番号: HY-131521
COA 取扱説明書 Technical Support

Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages.

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Oxalomalic acid trisodium

Oxalomalic acid trisodium 構造式

CAS 番号 : 89304-26-7

容量 価格（税別） 在庫状況 数量
1 mg $100 在庫あり
5 mg $245 在庫あり
10 mg $390 在庫あり
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100 mg   お問い合わせ  

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Oxalomalic acid trisodium 関連抗体

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製品説明

Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages[1].

体外実験

Oxalomalic acid trisodium (2.2, 5 mM; 2+24 h) reduces LPS-induced nitrite production and iNOS protein expression in J774 cells[1].
Oxalomalic acid trisodium (5 mM; 6, 12 h) shows no effect on the expression of iNOS mRNA in LPS-stimulated J774 macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxalomalic acid trisodium 関連抗体

Western Blot Analysis[1]

Cell Line: J774 cells
Concentration: 2.2, 5 mM (stimulated with LPS (1 μg/ml))
Incubation Time: 2+24 h
Result: Reduced in a significant and concentration-dependent manner nitrite production, reduced iNOS protein expression.
分子量

272.05

分子式

C6H3Na3O8
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C(C(C(O[Na])=O)O)C(O[Na])=O)=O)O[Na]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 1 mg/mL (3.68 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6758 mL 18.3790 mL 36.7579 mL
5 mM --- --- ---
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 95%

COA (251 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6758 mL 18.3790 mL 36.7580 mL 91.8949 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxalomalic acid trisodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxalomalic acid trisodium89304-26-7Oxalomalate trisodiumIsocitrate Dehydrogenase (IDH)LPSnitriteiNOS proteinJ774 cellsInhibitorinhibitorinhibit

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