Oxidopamine hydrochloride (Standard)
Oxidopamine hydrochloride (Standard) is the analytical standard of Oxidopamine hydrochloride (HY-B1081). This product is intended for research and analytical applications. Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytoKine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of ParKinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
For research use only. We do not sell to patients.
- CAS No.: 28094-15-7
- Formula: C8H12ClNO3
- Molecular Weight:205.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 28094-15-7
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Molecular Weight 205.64
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Formula C8H12ClNO3
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SMILES
OC1=CC(CCN)=C(O)C=C1O.[H]Cl
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Synonyms
6-Hydroxydopamine Hydrochloride (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. [Content Brief]
[2]. Jin F, et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600(1-3):78-82. [Content Brief]
[3]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. [Content Brief]
[4]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12. [Content Brief]
[6]. Ryan RE, et al. Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice. Br J Pharmacol. 2001 Apr;132(8):1650-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxidopamine hydrochloride (Standard) Related Classifications
HY-B1081R Related Classifications
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Keywords
- Oxidopamine hydrochloride (Standard)
- 28094-15-7
- 6-Hydroxydopamine Hydrochloride (Standard)
- Reference Standards
- Dopamine Receptor
- Autophagy
- COX
- PGE synthase
- Interleukin Related
- p38 MAPK
- Apoptosis
- Caspase
- neurotoxicity
- Parkinson’s disease
- Neuro-2a cells
- SH-SY5Y cells
- attention-deficit hyperactivity disorder
- Lesch-Nyhan syndrome
- PC12 cells
- p-p38
- PGE2
- Inhibitor
- inhibitor
- inhibit