2. MAPK/ERK Pathway
  3. MEK
  4. PD-334581

PD-334581 is a MEK1 inhibitor.

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PD-334581

PD-334581 화학구조

CAS No. : 548756-68-9

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg   견적 받기  
200 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of PD-334581:

PD-334581 Related Antibodies

Top Publications Citing Use of Products

View All MEK Isoform Specific Products:

View All Isoforms
MEK1 MEK2 MEK5 MEK MAP2K4/MEK4 MAP2K7/MEK7

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

PD-334581 is a MEK1 inhibitor[1].

IC50 & Target

MEK1

 

Cellular Effect
Cell Line Type Value Description References
Colon 26 IC50
0.032 M
Compound: 12J
Inhibition of MEK in mouse Colon 26 cells by Western blot
Inhibition of MEK in mouse Colon 26 cells by Western blot
[PMID: 18951019]
분자량

545.30

화학식

C20H19F3IN5O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

FC1=C(F)C(NC2=CC=C(C=C2F)I)=C(C3=NN=C(NCCN4CCOCC4)O3)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 12.5 mg/mL (22.92 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8339 mL 9.1693 mL 18.3385 mL
5 mM 0.3668 mL 1.8339 mL 3.6677 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8339 mL 9.1693 mL 18.3385 mL 45.8463 mL
5 mM 0.3668 mL 1.8339 mL 3.6677 mL 9.1693 mL
10 mM 0.1834 mL 0.9169 mL 1.8339 mL 4.5846 mL
15 mM 0.1223 mL 0.6113 mL 1.2226 mL 3.0564 mL
20 mM 0.0917 mL 0.4585 mL 0.9169 mL 2.2923 mL
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PD-334581 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-334581548756-68-9PD334581PD 334581MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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Inquiry Information

상품명:
PD-334581
Cat. No.:
HY-107619
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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