2. Protein Tyrosine Kinase/RTK
  3. PDGFR FLT3
  4. PDGFRα/FLT3-ITD-IN-3

PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of 0.153 and 0.004 μM, respectively. PDGFRα/FLT3-ITD-IN-3 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia.

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PDGFRα/FLT3-ITD-IN-3

PDGFRα/FLT3-ITD-IN-3 화학구조

CAS No. : 2761259-22-5

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PDGFRα/FLT3-ITD-IN-3 Related Antibodies

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제품 설명

PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of 0.153 and 0.004 μM, respectively. PDGFRα/FLT3-ITD-IN-3 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].

Cellular Effect
Cell Line Type Value Description References
EOL1 GI50
0.171 μM
Compound: 18d
Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein
Antiproliferative activity against human EOL1 cells expressing IP1L1-PDGFRA fusion protein
[PMID: 35124201]
K562 GI50
6.295 μM
Compound: 18d
Antiproliferative activity against human K562 cells
Antiproliferative activity against human K562 cells
[PMID: 35124201]
Kasumi 1 GI50
2.738 μM
Compound: 18d
Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant
Antiproliferative activity against human Kasumi 1 cells harboring N822K KIT mutant
[PMID: 35124201]
MV4-11 GI50
0.095 μM
Compound: 18d
Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant
Antiproliferative activity against human MV4-11 cells expressing FLT3-ITD mutant
[PMID: 35124201]
분자량

477.65

화학식

C26H39N9
CAS No.
SMILES

NCCCCNC1=CC=C(C=C1)NC2=NC(N[C@H]3CC[C@@H](CC3)N)=NC4=C2N=CN4C5CCCC5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PDGFRα/FLT3-ITD-IN-3 Related Classifications

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Keywords:

PDGFRα/FLT3-ITD-IN-32761259-22-5PDGFRFLT3Platelet-derived growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3PDGFRαacute myeloid leukemiachronic eosinophilic leukemiaInhibitorinhibitorinhibit

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PDGFRα/FLT3-ITD-IN-3
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HY-145904
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