PDGFRα kinase-IN-2
PDGFRα kinase-IN-2 is a potent PDGFR-α inhibitor with an IC50 of 2.1 nM. PDGFRα kinase-IN-2 exhibits anticancer activity against human colon cancer HT-29 cell with an IC50 of 1.48 μM. PDGFRα kinase-IN-2 has anti-angiogenic activity in zebrafish models and low embryonic lethality. PDGFRα kinase-IN-2 can used for the studies of colon cancer and anti-angiogenesis.
For research use only. We do not sell to patients.
- CAS No.: 3066103-58-7
- Formula: C24H23N5O3
- Molecular Weight:429.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDGFRα 2.1 nM (IC50) |
PDGFRα kinase-IN-2 (Compound 6o) (0.1-10 μM, 72 h) attenuates intersegmental vessels (ISVs) formation in a dose dependent manner in zebrafish and has better anti-angiogenesis ability than Sorafenib (HY-10201)[1].
Enpp-1-IN-27 (0.1-50 μM, 24 h) shows particularly low zebrafish embryonic lethality and is weaker than Sorafenib[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3066103-58-7
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Molecular Weight 429.47
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Formula C24H23N5O3
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SMILES
COC1=CC2=C(NC3=CC=C(NC(NC4=CC=CC(C)=C4)=O)C=C3)N=CN=C2C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDGFRα kinase-IN-2 Related Classifications
HY-175540 Related Classifications
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