3066103-58-7
Chemical Structure
PDGFRα kinase-IN-2
- No. CAS: 3066103-58-7
- Formula:C24H23N5O3
- Molecular Weight:429.47
IUPAC Name: 1-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)-3-(m-tolyl)urea
InChIKey: ZXLGTQIIRZVORL-UHFFFAOYSA-N
SMILES: COC1=CC2=C(NC3=CC=C(NC(NC4=CC=CC(C)=C4)=O)C=C3)N=CN=C2C=C1OC
Biological Activity: PDGFRα kinase-IN-2 is a potent PDGFR-α inhibitor with an IC50 of 2.1 nM. PDGFRα kinase-IN-2 exhibits anticancer activity against human colon cancer HT-29 cell with an IC50 of 1.48 μM. PDGFRα kinase-IN-2 has anti-angiogenic activity in zebrafish models and low embryonic lethality. PDGFRα kinase-IN-2 can used for the studies of colon cancer and anti-angiogenesis[1].
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PDGFRα kinase-IN-2 | PDGFRα kinase-IN-2 is a potent PDGFR-α inhibitor with an IC50 of 2.1 nM. PDGFRα kinase-IN-2 exhibits anticancer activity against human colon cancer HT-29 cell with an IC50 of 1.48 μM. PDGFRα kinase-IN-2 has anti-angiogenic activity in zebrafish models and low embryonic lethality. PDGFRα kinase-IN-2 can used for the studies of colon cancer and anti-angiogenesis. | |||||||||||||||||||||
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Keywords
