Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride
Based on 1 Customer Validation
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
For research use only. We do not sell to patients.
- Purity : 98.08%
- CAS No.: 2758431-93-3
- Formula: C23H31Cl2N5O4
- Molecular Weight:512.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Cereblon |
Chemical Information
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CAS No. 2758431-93-3
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Appearance Solid
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Molecular Weight 512.43
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Formula C23H31Cl2N5O4
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Color Light yellow to brown
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SMILES
O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (97.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (242 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9515 mL | 9.7574 mL | 19.5149 mL | 48.7872 mL |
| 5 mM | 0.3903 mL | 1.9515 mL | 3.9030 mL | 9.7574 mL | |
| 10 mM | 0.1951 mL | 0.9757 mL | 1.9515 mL | 4.8787 mL | |
| 15 mM | 0.1301 mL | 0.6505 mL | 1.3010 mL | 3.2525 mL | |
| 20 mM | 0.0976 mL | 0.4879 mL | 0.9757 mL | 2.4394 mL | |
| 25 mM | 0.0781 mL | 0.3903 mL | 0.7806 mL | 1.9515 mL | |
| 30 mM | 0.0650 mL | 0.3252 mL | 0.6505 mL | 1.6262 mL | |
| 40 mM | 0.0488 mL | 0.2439 mL | 0.4879 mL | 1.2197 mL | |
| 50 mM | 0.0390 mL | 0.1951 mL | 0.3903 mL | 0.9757 mL | |
| 60 mM | 0.0325 mL | 0.1626 mL | 0.3252 mL | 0.8131 mL | |
| 80 mM | 0.0244 mL | 0.1220 mL | 0.2439 mL | 0.6098 mL |
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride Related Classifications
HY-160244 Related Classifications
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