Retinoid X Receptor alpha

The retinoid X receptor (RXR) belongs to the steroid/thyroid hormone superfamily of nuclear receptors (NRs) and includes RXRα, β, and γ (NR2B1, NR2B2 and NR2B3). They feature a modular structure, which can be dissected in several domains with associated functions, most notably the N-terminal activation function (AF-1), the central DNA-binding domain (DBD) and the C-terminal ligand-binding domain (LBD). RXRs can act as the heterodimerization partner of many nuclear receptors, including vitamin D receptor (VDR), thyroid hormone receptor (TR), retinoic acid receptor (RAR), peroxisome proliferator-activated receptor (PPAR), Farnesoid X Receptor (FXR), and a number of orphan receptors. RXRs function as transcription factors and thus regulate a wide variety of cellular processes, including inflammation, development, differentiation, apoptosis, and metabolism.