Two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum

  • Bioorg Med Chem Lett. 2009 Jan 1;19(1):192-5. doi: 10.1016/j.bmcl.2008.10.121.
P Prabhakar Reddy  1 ,  R Ranga Rao ,  K Rekha ,  K Suresh Babu ,  J Shashidhar ,  G Shashikiran ,  V Vijaya Lakshmi ,  J Madhusudana Rao
Affiliations
  • 1. Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad, India.
PMID: 19027298 DOI: 10.1016/j.bmcl.2008.10.121
Abstract

Phytochemical investigation of CHCl(3) extract of the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpenes, compounds 1 and 2 along with five known compounds (3-7). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against the Colo-205 (Colo-cancer), A-431 (skin Cancer), MCF-7 (breast Cancer), A-549 (lung Cancer) and Chinese hamster ovary cells (CHO). Two new compounds 1 and 2 were shown good cytotoxic activity.