In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft

  • Int J Med Sci. 2022 May 21;19(5):952-964. doi: 10.7150/ijms.62438.
Lijun Zhang  1  2 ,  Guangchao Xu  1 ,  Yating Wei  1 ,  Mingzhou Yuan  2 ,  Yuanyuan Li  1  2 ,  Meifang Yin  1  2 ,  Chufen Chen  2 ,  Guangtao Huang  1 ,  Bin Shu  2 ,  Jun Wu  1  2  3
Affiliations
  • 1. Department of Burns and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, P.R. China.
  • 2. Department of Burns, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.
  • 3. Human Histology & Embryology Section, Department of Surgery, Dentistry, Pediatrics & Gynecology, University of Verona Medical School, Italy.
PMID: 35693752 DOI: 10.7150/ijms.62438
Abstract

Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the "perfect regenerative healing" of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds.

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