FOXP3 Protein, Human (431a.a, His)

FOXP3, a pivotal transcriptional regulator, is indispensable for the development and inhibitory function of regulatory T-cells (Treg), playing a crucial role in maintaining immune system homeostasis. It acts as both a transcriptional repressor and activator, influencing the Treg lineage's suppressive function and stability, while modulating conventional T-cell expansion and function. FOXP3 coordinates the activation of key genes like CTLA4 and TNFRSF18, concomitant with the repression of cytokine-encoding genes such as interleukin-2 (IL2) and interferon-gamma (IFNG). Through its association with various transcription factors and chromatin modifiers, FOXP3 inhibits cytokine production, T-cell effector function, and the differentiation of IL17-producing helper T-cells (Th17), favoring Treg development. FOXP3's interactions with proteins like IKZF3, RUNX1, RORC, RELA, NFATC2, and others contribute to its diverse regulatory functions. Dimerization is essential for its transcriptional regulator activity, and it forms complexes with proteins such as STUB1, HSPA8, PPP1CA, PPP1CB, KAT5, HDAC7, USP7, ZFP90, TRIM28, RUNX2, RUNX3, and IKZF4.