(S,R,S)-AHPC(Me)-amido-C2-acid

製品番号: HY-164043 純度: 95.05%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

(S,R,S)-AHPC(Me)-amido-C2-acid 構造式

CAS 番号 : 2365173-01-7

容量	価格（税別）	在庫状況	数量
5 mg	$47	在庫あり	Estimated Time of Arrival: December 31
10 mg	$71	在庫あり	Estimated Time of Arrival: December 31
25 mg	$116	在庫あり	Estimated Time of Arrival: December 31
50 mg	$175	お問い合わせ
100 mg	$262	お問い合わせ
250 mg	$517	お問い合わせ
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036)^[1].

IC₅₀ & Target

VHL

分子量

544.66

分子式

C₂₇H₃₆N₄O₆S

CAS 番号

2365173-01-7

Appearance

Solid

Color

White to off-white

SMILES

OC(CCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (45.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8360 mL	9.1800 mL	18.3601 mL
5 mM	0.3672 mL	1.8360 mL	3.6720 mL
10 mM	0.1836 mL	0.9180 mL	1.8360 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 95.05%

Select Batch:

データシート (278 KB) SDS (252 KB)

COA (260 KB) HNMR (294 KB) LCMS (104 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8360 mL	9.1800 mL	18.3601 mL	45.9002 mL
	5 mM	0.3672 mL	1.8360 mL	3.6720 mL	9.1800 mL
	10 mM	0.1836 mL	0.9180 mL	1.8360 mL	4.5900 mL
	15 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0600 mL
	20 mM	0.0918 mL	0.4590 mL	0.9180 mL	2.2950 mL
	25 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	30 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	40 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1475 mL