(S,R,S)-AHPC(Me)-amido-C2-acid

Cat. No.: HY-164043 Pureza: 95.05%: Ficha de datos
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(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036).

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(S,R,S)-AHPC(Me)-amido-C2-acid Estructura química

No. CAS : 2365173-01-7

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
100 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
250 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto
1 g	Obtener un presupuesto

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Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Ligands for E3 Ligase:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

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Descripciòn

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036)^[1].

IC₅₀ & Target

VHL

Peso molecular

544.66

Fòrmula

C₂₇H₃₆N₄O₆S

No. CAS

2365173-01-7

Appearance

Solid

Color

White to off-white

SMILES

OC(CCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 25 mg/mL (45.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8360 mL	9.1800 mL	18.3601 mL
5 mM	0.3672 mL	1.8360 mL	3.6720 mL
10 mM	0.1836 mL	0.9180 mL	1.8360 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 95.05%

Select Batch:

Ficha de datos (278 KB) SDS (252 KB)

COA (260 KB) HNMR (294 KB) LCMS (104 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8360 mL	9.1800 mL	18.3601 mL	45.9002 mL
	5 mM	0.3672 mL	1.8360 mL	3.6720 mL	9.1800 mL
	10 mM	0.1836 mL	0.9180 mL	1.8360 mL	4.5900 mL
	15 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0600 mL
	20 mM	0.0918 mL	0.4590 mL	0.9180 mL	2.2950 mL
	25 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	30 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	40 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1475 mL