(S,R,S)-AHPC(Me)-amido-C2-acid

Art. -Nr.: HY-164043 Reinheit: 95.05%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036).

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(S,R,S)-AHPC(Me)-amido-C2-acid Chemische Struktur

CAS. Nr. : 2365173-01-7

Größe	Verfügbarkeit	Menge
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen	Estimated Time of Arrival: December 31
100 mg	Angebot einholen	Estimated Time of Arrival: December 31
250 mg	Angebot einholen	Estimated Time of Arrival: December 31
500 mg	Angebot einholen
1 g	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

(S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036)^[1].

IC₅₀ & Target

VHL

Molekulargewicht

544.66

Formel

C₂₇H₃₆N₄O₆S

CAS. Nr.

2365173-01-7

Appearance

Solid

Color

White to off-white

SMILES

OC(CCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (45.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8360 mL	9.1800 mL	18.3601 mL
5 mM	0.3672 mL	1.8360 mL	3.6720 mL
10 mM	0.1836 mL	0.9180 mL	1.8360 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 95.05%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (260 KB) HNMR (294 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8360 mL	9.1800 mL	18.3601 mL	45.9002 mL
	5 mM	0.3672 mL	1.8360 mL	3.6720 mL	9.1800 mL
	10 mM	0.1836 mL	0.9180 mL	1.8360 mL	4.5900 mL
	15 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0600 mL
	20 mM	0.0918 mL	0.4590 mL	0.9180 mL	2.2950 mL
	25 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	30 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	40 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1475 mL