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Cinnamyl Alcohol

Cat. No.: HY-Y0078

Cinnamyl Alcohol

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities.

For research use only. We do not sell to patients.

Purity: 98.58%
CAS No.: 104-54-1
Formula: C₉H₁₀O
Molecular Weight:134.18

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cinnamyl Alcohol Chemical Structure

CAS No.: 104-54-1

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(In Japan)

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, exhibits anti-obesity, antioxidant and anti-inflammatory activities^[1].

All NO Synthase Isoforms :

All ERK Isoforms :

All ROCK Isoforms :

All AMPK Isoforms :

All Akt Isoforms :

All PPAR Isoforms :

In Vitro

Cinnamyl Alcohol (0.5-1 µg/µL, 24 h) inhibits LPS (HY-D1056) and IFN-γ-induced NO production in cell RAW264.7 through inhibition of iNOS^[4].
Cinnamyl Alcohol (0.4-2 mM, 24 h) activates K+ channels via the NO-cGMP-PKG pathway, inhibits Rho kinase, and attenuates Phenylephrine (HY-B0769)-induced vasoconstriction in rat thoracic aorta endothelial cells^[3].
Cinnamyl Alcohol (25 µM, 24-48 h) downregulates the expressions of adipogenesis-related proteins PPARγ, C/EBPα, FABP4 and adipogenesis-related proteins C/EBPβ, C/EBPδ, cyclin B1/D1/E1, and CDK2/6, arrests cell cycle at G0/G1 phase in 3T3-L1 cells, and inhibits the lipid accumulation^[2].
Cinnamyl Alcohol (25 µM, 60 min) activates the AMPKα phosphorylation, inhibits AKT and ERK1/2 signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

3T3-L1
Concentration:

25 µM
Incubation Time:

16-20 h
Result:

Downregulated expressions of PPARγ, C/EBPα, FABP4, C/EBPβ, C/EBPδ, cyclin B1/D1/E1, CDK2/6.

Cell Cycle Analysis^[2]

Cell Line:

3T3-L1
Concentration:

25 µM
Incubation Time:

24-48 h
Result:

Arrested cell cycle at G0/G1 phase.

Western Blot Analysis^[4]

Cell Line:

RAW246.7
Concentration:

0.5-1 µg/µL
Incubation Time:

24 h
Result:

Inhibited expression of iNOS.

In Vivo

Cinnamyl Alcohol (2 g/kg, po, single dose) exhibits anti-inflammatory activity in E. coli-induced sepsis mouse model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse E. coli-induced sepsis model^[5]
Dosage:

2 g/kg
Administration:

po, single dose
Result:

Reduced the inflammatory reaction in the liver, heart, lungs, and kidneys

Chemical Information

CAS No. 104-54-1
Appearance <30°C Solid,>33°C Liquid
Molecular Weight 134.18
Formula C₉H₁₀O
Color White to light yellow
SMILES

OC/C=C/C1=CC=CC=C1
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
Initial Source
- Plants
- Fagaceae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

PLoS Biol

A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans. [Abstract]

2024 Jun 27;22(6):e3002672. PMID: 38935621
bioRxiv

An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]

2024 Apr 3:2023.06.02.542933. PMID: 37333363

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1490.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (745.27 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

7.4527 mL

37.2634 mL

74.5268 mL

5 mM

1.4905 mL

7.4527 mL

14.9054 mL

10 mM

0.7453 mL

3.7263 mL

7.4527 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (37.26 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Portuguese - PT (796 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hwang DI, et al. Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors. Am J Chin Med. 2017;45(4):833-846. [Content Brief]

[2]. Choi YR, et al., Cinnamyl Alcohol Attenuates Adipogenesis in 3T3-L1 Cells by Arresting the Cell Cycle. Int J Mol Sci. 2024 Jan 5;25(2):693. [Content Brief]

[3]. Kang YH, et al., Cinnamyl alcohol attenuates vasoconstriction by activation of K⁺ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase. Exp Mol Med. 2012 Dec 31;44(12):749-55. [Content Brief]

[4]. Lee H S. Chemical composition of Cinnamomum cassia leaf oils and suppression effect of cinnamyl alcohol on nitric oxide synthase[J]. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52: 480-485.

[5]. Zou L, et al., The anti-inflammatory effects of cinnamyl alcohol on sepsis-induced mice via the NLRP3 inflammasome pathway. Ann Transl Med. 2022 Jan;10(2):48. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	7.4527 mL	37.2634 mL	74.5268 mL	186.3169 mL
	5 mM	1.4905 mL	7.4527 mL	14.9054 mL	37.2634 mL
	10 mM	0.7453 mL	3.7263 mL	7.4527 mL	18.6317 mL
	15 mM	0.4968 mL	2.4842 mL	4.9685 mL	12.4211 mL
	20 mM	0.3726 mL	1.8632 mL	3.7263 mL	9.3158 mL
	25 mM	0.2981 mL	1.4905 mL	2.9811 mL	7.4527 mL
	30 mM	0.2484 mL	1.2421 mL	2.4842 mL	6.2106 mL
	40 mM	0.1863 mL	0.9316 mL	1.8632 mL	4.6579 mL
	50 mM	0.1491 mL	0.7453 mL	1.4905 mL	3.7263 mL
	60 mM	0.1242 mL	0.6211 mL	1.2421 mL	3.1053 mL
	80 mM	0.0932 mL	0.4658 mL	0.9316 mL	2.3290 mL
	100 mM	0.0745 mL	0.3726 mL	0.7453 mL	1.8632 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cinnamyl Alcohol

2 Cited Publications

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Cinnamyl Alcohol

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

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