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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
59 Results for "
DNA modification
" in MedChemExpress (MCE) Product Catalog:
Products (59)
59 Results for "DNA modification" in MCE Product Catalog:
Art. -Nr.: HY-I0626S2
CAS. Nr.: 106391-24-6
Art. -Nr.: HY-159925
CAS. Nr.: 2646682-38-2
Target:
Forschungsgebiete:
QKY-613 is a prodrug that enhances immune surveillance by targeting nucleic acid modification pathways. QKY-613 promotes the selective incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, enhancing the phase separation potential of DNA, thereby increasing the activation of cGAS and strengthening host immune surveillance. In virus-infected mouse models, QKY-613 significantly reduced mortality in aged mice. QKY-613 holds promise for research on nucleic acid modification-based immune surveillance mechanisms .
Art. -Nr.: HY-I0626S1
CAS. Nr.: 181517-10-2
Art. -Nr.: HY-135782A
Forschungsgebiete:
iso-ADP ribose TEA is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose TEA specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose TEA can be used for cancer research .
Art. -Nr.: HY-112764GL
CAS. Nr.: 160743-62-4
Art. -Nr.: HY-171334
CAS. Nr.: 2957895-04-2
Forschungsgebiete:
(Rac)-P1D-34 is a Pin1 PROTAC degrader that recruits cereblon, with a DC50 of 177 nM. (Rac)-P1D-34 induces Pin1 degradation via proteasome- and ubiquitin-like modification-dependent pathways. (Rac)-P1D-34 upregulates ROS and DNA damage, downregulates the UPR pathway, and inhibits leukemia cell proliferation; it also sensitizes drug-resistant acute myeloid leukemia cells to Venetoclax (ABT-199) (HY-15531) by downregulating Mcl-1 levels. (Rac)-P1D-34 can be used in the research of acute myeloid leukemia .
Art. -Nr.: HY-176960
CAS. Nr.: 141895-16-1
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Forschungsgebiete:
3-Amino-2-hydroxypropyl dihydrogen phosphate is a chemical modification complex of the DNA phosphate backbone, which can be used to study the interaction between HIV integrase (IN) and DNA .
Art. -Nr.: HY-155869
CAS. Nr.: 79671-09-3
Synonyms: 5-Fluoro-2′-deoxycytidine 5′-triphosphate
Target:
Forschungsgebiete:
5-fluoro-dCTP is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
Art. -Nr.: HY-I0626S
CAS. Nr.: 285978-06-5
Art. -Nr.: HY-134902
CAS. Nr.: 537039-67-1
Synonyms: UDP-α-6N3-glucose; 6-Azidoglucose-UDP
Forschungsgebiete:
UDP-6-azido-6-Deoxy-D-Glc (UDP-α-6N3-glucose; 6-Azidoglucose-UDP) is a UDP-sugar donor . UDP-6-azido-6-Deoxy-D-Glc is used for the selective labeling of 5-hmC in genomic DNA. UDP-6-azido-6-Deoxy-D-Glc enables glyco-diversification modification of saponin intermediates and click chemistry-based derivatization .
Art. -Nr.: HY-W1119950
CAS. Nr.: 1644649-86-4
Forschungsgebiete:
3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing .
Art. -Nr.: HY-153421
CAS. Nr.: 2242753-66-6
Target:
Forschungsgebiete:
PRMT5-IN-28 (compound 36) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) enzyme. Protein arginine methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape .
Art. -Nr.: HY-163592
CAS. Nr.: 3034746-11-4
Target:
Forschungsgebiete:
PRMT5-IN-43 (compound 4A) is a PRMT5 inhibitor. PRMT5-IN-43 can be used in cancer research .
Art. -Nr.: HY-163593
CAS. Nr.: 3034746-35-2
Target:
Forschungsgebiete:
PRMT5-IN-44 (compound 12) is a PRMT5 inhibitor. PRMT5-IN-44 can be used in cancer research .
Art. -Nr.: HY-160199
CAS. Nr.: 213206-31-6
Target:
Forschungsgebiete:
3'-L-Histidyl-AMP is applicable for nucleoside modification (DNA, RNA) .
Art. -Nr.: HY-160199A
Target:
Forschungsgebiete:
3'-L-histidyl-AMP (disodium) is applicable for nucleoside modification (DNA, RNA) .
Art. -Nr.: HY-155869A
Synonyms: 5-Fluoro-2′-deoxycytidine 5′-triphosphate sodium
Target:
Forschungsgebiete:
5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
Art. -Nr.: HY-134355
CAS. Nr.: 53595-18-9
ADPRP is an intranuclear enzyme whose main activity is to use NAD+ (nicotinamide adenine dinucleotide) as a substrate to add ADP-ribose units to chromatin-bound proteins, including the ADPRP enzyme itself. This process, called poly(ADP-ribosylation), is a post-translational modification that regulates the interaction between DNA and nuclear proteins .
Art. -Nr.: HY-171334A
Forschungsgebiete:
P1D-34 is a potent PIN1 PROTAC degrader with a DC50 of 177 nM. P1D-34 induces PIN1 degradation in a proteasome- and ubiquitination-like modification-dependent manner, thereby increasing intracellular ROS levels, downregulating the unfolded protein response pathway, and inducing DNA damage, cell cycle arrest and apoptosis. P1D-34 can be used in studies related to acute myeloid leukemia .
Art. -Nr.: HY-W767399
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
