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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
68 Results for "
Eif4e
" in MedChemExpress (MCE) Product Catalog:
Products (68)
68 Results for "Eif4e" in MCE Product Catalog:
Cat. No.: HY-148664
CAS No.: 1373822-39-9
Research Areas:
eIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical
activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .
Cat. No.: HY-145974
CAS No.: 62858-30-4
Synonyms: m7G(5')ppp(5')(2'OMeA)pG
Research Areas:
m7GpppAmpG (m7G(5')ppp(5')(2'OMeA)pG) is a trinucleotide 5′ cap analog. m7GpppAmpG binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG caps RNA with an efficiency of 90% and enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research .
Cat. No.: HY-176288
Research Areas:
eIF4E/eIF4G PPI-IN-1 is an eIF4E/eIF4G interaction inhibitor with a KD of 20.2 μM for eIF4E protein. eIF4E/eIF4G PPI-IN-1 plays an antitumor role in multiple modes of action including regulating the activity of eIF4E by inhibiting the Ras/MAPK/eIF4E signaling pathway, apoptosis and cell migration. eIF4E/eIF4G PPI-IN-1 suppresses the growth of HepG2 xenografts in nude mice and was relatively nontoxic to mice .
Cat. No.: HY-RS17829
Target:
Research Areas:
Eif4e Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eif4e gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24297
Target:
Research Areas:
Eif4e Rat Pre-designed siRNA Set A contains three designed siRNAs for Eif4e gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-155676
Research Areas:
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .
Cat. No.: HY-155337
Research Areas:
eIF4E-IN-6(compound 4b) is a GMP analogs synthesized to targeteIF4Eand restrain its binding to cap mRNA.eIF4E-IN-6shows cell cytotoxicity against Caco-2, HepG-2,and MCF-7 cells, withIC50values of 31, 27, and 21 μM, respectively .
Cat. No.: HY-100022A
CAS No.: 1849590-02-8
Synonyms: eFT508 hydrochloride
Target:
Research Areas:
Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines . Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance .
Cat. No.: HY-145976
CAS No.: 133608-76-1
Research Areas:
m7GpppGpG is an unmodified trinucleotide cap analog with enhancer activity. When incorporated into mRNA, it effectively enhances translational efficiency, stability, and protein expression levels of the mRNA. m7GpppGpG can serve as a standard cap analog for in vitro mRNA synthesis to support antigen generation and presentation by dendritic cells, although its expression efficiency in dendritic cells is 20-fold lower than that of the m7GpppApG cap .
Cat. No.: HY-W846144
CAS No.: 794510-70-6
ETP-45835 is slective and potent MNK inhibitor with IC50s of 575 nM and 646 nM for MNK1 and MNK2, respectively. ETP-45835 shows little activity against 24 other kinases. ETP-45835 inhibits eIF4E Ser209 phosphorylation in cells, and has anticancer effects .
Cat. No.: HY-163479
CAS No.: 2548283-27-6
Research Areas:
MNK1/2-IN-7 (compound 20j) is an orally available inhibitor of MNK1/2 with anticancer activity and hERG safety. MNK1/2-IN-7 also inhibits the phosphorylation of eIF4E, inhibiting the MNK/eIF4E signaling pathway and cancer cell proliferation. MNK1/2-IN-7 is synergistic with Ibrutinib (HY-109970) .
Cat. No.: HY-P70152
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Eif4e; Eif-4F 25 KDa Subunit; Prev. Eif4eL1; Eukaryotic Translation Initiation Factor 4e-Like 1; Prev. Eif4F; AUTS19; Eif4e1; CBP; MRNA Cap-Binding Protein; Eukaryotic Translation Initiation Factor 4e; Eif-4e
Species:
Human
Source:
E. coli
Cat. No.: HY-RS04275
Target:
Research Areas:
EIF4E2 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4E2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS04276
Target:
Research Areas:
EIF4E3 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4E3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-187368
Research Areas:
(S)-DMP2 is a benzoxaborole-derived photoaffinity probe that efficiently enriches eukaryotic translation initiation factor 4E (eIF4E) with stereoselectivity. (S)-DMP2 acts as a cap-binding competitive inhibitor that competes with the 7-methylguanosine cap of mRNA for binding at the cap-binding pocket of eIF4E, covalently modifies residues within this pocket, and impairs the cap-binding ability of eIF4E. (S)-DMP2 is applicable to research on eIF4E-related mechanisms and diseases .
Cat. No.: HY-178672
CAS No.: 400806-46-4
Synonyms: Anti-Reverse cap analog; m2 7,3′O GpppG
Target:
ARCA (Anti-Reverse cap analog; m2 7,3'OGpppG) is a 5′-cap analog. ARCA carries a methyl group at the 3'-OH position of m7G, which ensures that the cap is ligated to the 5' end of mRNA in the correct orientation during in vitro transcription and prevents reverse ligation. ARCA enhances the translation efficiency and stability of mRNA. In human immature dendritic cells, both the translation efficiency and total protein expression of ARCA-capped mRNA are higher than those of conventional m7GpppG-capped mRNA. ARCA can be used in research related to cancer, infectious diseases and mRNA vaccines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
