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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
MetAP
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "MetAP" in MCE Product Catalog:
Cat. No.: HY-116861
CAS No.: 369358-07-6
A-357300 is a reversible and selective MetAP2 inhibitor with IC50s of 0.12 and 57 μM against MetAP2 and MetAP1. A-357300 induces cytostasis by cell cycle arrest at the G1 phase selectively in endothelial cells and in a subset of tumor cells. A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. A-357300 can be used for the studies of neuroblastoma, fibrosarcoma and breast cancer .
TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells .
Cat. No.: HY-RS08348
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METAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17313
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Metap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Metap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08349
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METAP1D Human Pre-designed siRNA Set A contains three designed siRNAs for METAP1D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26041
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Metap1d Rat Pre-designed siRNA Set A contains three designed siRNAs for Metap1d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W282615
CAS No.: 341944-06-7
Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection .
Cat. No.: HY-184384
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MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma .
Cat. No.: HY-RS17853
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Metap2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Metap2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23768
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Metap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Metap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24322
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Metap2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Metap2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19545
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Metap1d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Metap1d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-122225
CAS No.: 836671-12-6
JNJ-4929821 (Compound 88), a triazole derivative, is a selective Methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 15 nM over MetAP-1. JNJ-4929821 can be used for cancers like liver cancer, colorectal adenocarcinoma and pancreatic cancer research .
Cat. No.: HY-182419
CAS No.: 904680-01-9
A-849519 is a reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 19 nM. A-849519 binds to the active site of the Mn 2+ form of human MetAP-2, where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2 as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma .
Cat. No.: HY-184777
CAS No.: 94367-34-7
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Met-AMC is a fluorescent substrate used to detect the activity of methionine aminopeptidase (MetAP). Hydrolysis of the substrate releases the fluorophore AMC, with detection performed at an excitation wavelength of 360 nm and an emission wavelength of 460 nm. Met-AMC can distinguish the effects of different metal cofactors on the substrate preference of MetAP1: Zn (II)-MetAP1 barely hydrolyzes Met-AMC, while Co (II)-, Mn (II)-, and Ni (II)-MetAP1 can stably cleave this substrate. Met-AMC can be used to establish an intracellular MetAP activity cell-based assay system, which quantifies the intracellular MetAP inhibition level by monitoring the fluorescence signal from substrate hydrolysis in living cells .
Cat. No.: HY-181643
CAS No.: 3075693-57-8
YOK24 is an orally active MetAP2 inhibitor and anti-amoebic agent. YOK24 binds covalently to MetAP2 and inhibits its peptidase activity, where MetAP2 is a protein essential for the proliferation of *Entamoeba histolytica*. YOK24 can be used in the research of amoebiasis .
Cat. No.: HY-183876
CAS No.: 661482-39-9
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LAF-153 is a Methionine Aminopeptidase-2 (MetAP-2) inhibitor with human IC50 values of 0.074 μM and 0.16 μM.LAF-153 has a t-butyl group extending into the innermost portion of the MetAP-2 cleft, a lactam ring coordinated in the enzyme’s shallow surface pocket, and three hydroxyl groups coordinating to the two cobalt ions in the enzyme’s active site .
Cat. No.: HY-P70862
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MetAP1D; Peptidase M 1D; Methionyl Aminopeptidase Type 1D, Mitochondrial; MetAP 1D; MAP1D; MAP 1D; MetAP1l; CDS Of MetAP-3 Within PCR Fragment; Methionine Aminopeptidase 1D, Mitochondrial; Methionine Aminopeptidase 1D
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
