1. Anti-infection
  2. Bacterial
  3. Antibacterial agent 117

Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection.

For research use only. We do not sell to patients.

Antibacterial agent 117 Chemical Structure

Antibacterial agent 117 Chemical Structure

CAS No. : 341944-06-7

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Based on 1 publication(s) in Google Scholar

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Description

Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].

IC50 & Target

IC50: 15 μM (RpMetAP1)[1]

In Vitro

Antibacterial agent 117 can inhibit RpMetAP1 with an IC50 value of 15 μM[1].
Antibacterial agent 117 (0.3 μM, 3 μM, 30 μM and 300 μM) stimulates endothelial cell (EC) metabolism and also inhibits rickettsial growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

240.71

Formula

C9H9ClN4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NNC(SCC2=CC=CC=C2Cl)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (415.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1544 mL 20.7719 mL 41.5438 mL
5 mM 0.8309 mL 4.1544 mL 8.3088 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1544 mL 20.7719 mL 41.5438 mL 103.8594 mL
5 mM 0.8309 mL 4.1544 mL 8.3088 mL 20.7719 mL
10 mM 0.4154 mL 2.0772 mL 4.1544 mL 10.3859 mL
15 mM 0.2770 mL 1.3848 mL 2.7696 mL 6.9240 mL
20 mM 0.2077 mL 1.0386 mL 2.0772 mL 5.1930 mL
25 mM 0.1662 mL 0.8309 mL 1.6618 mL 4.1544 mL
30 mM 0.1385 mL 0.6924 mL 1.3848 mL 3.4620 mL
40 mM 0.1039 mL 0.5193 mL 1.0386 mL 2.5965 mL
50 mM 0.0831 mL 0.4154 mL 0.8309 mL 2.0772 mL
60 mM 0.0692 mL 0.3462 mL 0.6924 mL 1.7310 mL
80 mM 0.0519 mL 0.2596 mL 0.5193 mL 1.2982 mL
100 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0386 mL
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Antibacterial agent 117 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antibacterial agent 117
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HY-W282615
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