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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
SNIPER
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "SNIPER" in MCE Product Catalog:
Research Areas:
HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
Cat. No.: HY-128818
CAS No.: 2113688-20-1
Synonyms: E3 ligase Ligand-Linker Conjugates 39
Research Areas:
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs .
Cat. No.: HY-128806
CAS No.: 87304-15-2
Target:
Research Areas:
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins .
Cat. No.: HY-111842
CAS No.: 1225383-41-4
Research Areas:
PROTAC CRABP-II Degrader-3 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-3 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-3 can be used for the research of neuroblastoma .
Cat. No.: HY-176440
Target:
Research Areas:
BP-198 is a inhibitor and a SNIPER-class degrader targeting to SARS-CoV-2 main protease (Mpro) , with antiviral activity. BP-198 recruits the IAP ubiquitin ligase complex to degrade target proteins via the ubiquitin-proteasome system. BP-198 also degrades protease mutants resistant to Nirmatrelvir (HY-138687). BP-198 can be used in studies related to COVID-19 .
Cat. No.: HY-111877A
SNIPER(TACC3)-2 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-2 hydrochloride induces cancer cell death .
Cat. No.: HY-111871
CAS No.: 2222354-18-7
SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM (ABL inhibitor: HY-15814; ABL inhibitor activity control: HY-131178; E3 ligase ligand: HY-128808; linker: HY-130500; E3 ligase ligand + linker: HY-128819) .
Cat. No.: HY-111876A
SNIPERTACC3-1 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPERTACC3-1 hydrochloride induces cancer cell death .
Cat. No.: HY-130270
CAS No.: 2380012-98-4
Synonyms: E3 Ligase Ligand-Linker Conjugates 57
Research Areas:
AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) incorporates an IAP ligand for the E3 ubiquitin ligase, and a SNIPER linker. AhR Ligand-Linker Conjugates 1 can be used to design SNIPER .
Cat. No.: HY-111852
CAS No.: 778277-37-5
Synonyms: PROTAC ABL binding moiety 2
Research Areas:
GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
Cat. No.: HY-111853
CAS No.: 2095244-62-3
Synonyms: PROTAC IAP binding moiety 2
Target:
Research Areas:
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .
Cat. No.: HY-111855
CAS No.: 2444044-44-2
Synonyms: PROTAC ABL binding moiety 3
Research Areas:
HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .
Cat. No.: HY-128812
CAS No.: 1239943-19-1
Synonyms: E3 ligase Ligand-Linker Conjugates 33
Research Areas:
cIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
