1225383-41-4
Chemical Structure
PROTAC CRABP-II Degrader-3
- CAS No.: 1225383-41-4
- Formula:C46H68N4O11
- Molecular Weight:853.05
IUPAC Name: (2E,4E,6E,8E)-9-((E)-3-((((17S,20S,21R)-21-amino-20-hydroxy-17-isobutyl-2,16,19-trioxo-22-phenyl-6,9,12,15-tetraoxa-3,18-diazadocosyl)oxy)imino)-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
InChIKey: RZIQIEBBFSSCIQ-KMRDRQGYSA-N
SMILES: CC(/C=C/C=C(/C=C/C1=C(/C(CCC(C)1C)=N/OCC(NCCOCCOCCOCCOC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC2=CC=CC=C2)=O)=O)=O)C)C)=C\C(O)=O
Biological Activity: PROTAC CRABP-II Degrader-3 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-3 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-3 can be used for the research of neuroblastoma[1].
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PROTAC CRABP-II Degrader-3 | PROTAC CRABP-II Degrader-3 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-3 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-3 can be used for the research of neuroblastoma. | |||||||||||||||||||||
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Keywords
