50 Results for "

gap junction

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "gap junction" in MCE Product Catalog:

Cat. No.: HY-P10886
CAS No.: 1465809-36-2
Research Areas:  

Inflammation/Immunology

Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .
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Cat. No.: HY-W248583
CAS No.: 157410-23-6
Synonyms: PM650
Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
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Cat. No.: HY-10913
CAS No.: 943134-39-2
Synonyms: gap-134; ZP 1609
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect .
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Cat. No.: HY-D1777
CAS No.: 137829-80-2
Synonyms: PM605
Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
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Cat. No.: HY-P11197
CAS No.: 895547-36-1
Target:  

Gap Junction Protein

Research Areas:  

Cancer

ACT1 is a peptide that targets endogenous Cx43 by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research .
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Cat. No.: HY-106225R
CAS No.: 355151-12-1
Synonyms: ZP123 (Standard)
Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .
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Cat. No.: HY-B1588S
Carbenoxolone-d4 is the d4 labeled Carbenoxolone (HY-B1588). Carbenoxolone is a blood-brain barrier-permeable Pannexin1 inhibitor, gap junction (Gap junction) blocker, and β-amyloid 42 inhibitor. Carbenoxolone modulates voltage-gated currents of wild-type and mutant Panx1, and inhibits stimulus-activated Panx1 channel function. Carbenoxolone interacts with stable residues of β-amyloid 42 peptides, fibrils and oligomers, thereby inhibiting their aggregation. Carbenoxolone alleviates liver fibrosis. Carbenoxolone exerts neuroprotective and nootropic effects. Carbenoxolone can be used in studies related to Alzheimer's disease and liver fibrosis .
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Cat. No.: HY-P5389
CAS No.: 403858-30-0
Target:  

Gap Junction Protein

Research Areas:  

Others

Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)
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Cat. No.: HY-W010653R
CAS No.: 6683-19-8
Synonyms: lrganox 1010 (Standard); AT1010 (Standard)
Research Areas:  

Others

Antioxidant 1010 (Standard) is the analytical standard of Antioxidant 1010 (lrganox 1010; AT1010) (HY-W010653) . This product is intended for research and analytical applications. Antioxidant 1010 is a hindered phenolic antioxidant. Antioxidant 1010 does not inhibit intercellular gap-junctional communication. Antioxidant 1010 exhibits antioxidant efficacy in plastic, rubber and synthetic fiber ..
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Cat. No.: HY-117275R
CAS No.: 644-62-2
Synonyms: Meclofenamate (Standard)
Meclofenamic acid (Standard) is the analytical standard of Meclofenamic acid. This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively .
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Cat. No.: HY-14584
CAS No.: 955995-48-9
Research Areas:  

Cancer

PQ-1 is a gap junction enhancer.
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Cat. No.: HY-10913S
Synonyms: gap-134-d5; ZP 1609-d5
Danegaptide-d5 (GAP-134-d5) is deuterium labeled Danegaptide. Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect .
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Cat. No.: HY-14584A
CAS No.: 955995-51-4
Research Areas:  

Others

PQ-1 succinate is an inhibitor for gap junction, which suppresses the gap junction dye transfer activity in retinal neurosensory R28 cells, and inhibits the CoCl2-induced ischemic apoptosis in retinal cell .
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Cat. No.: HY-P5387
CAS No.: 514787-21-4
Target:  

Inhibitory Antibodies

Research Areas:  

Others

Connexin mimetic peptide 40,37GAP26 is a biological active peptide. (This peptide corresponds to the GAP26 domain of the extracellular loop of the major vascular connexins (Cx37, Cx40), designated as 37, 40Gap 26 according to Cx homology. It was used to investigate the role of gap junctions in the spread of endothelial hyperpolarizations evoked by cyclopiazonic acid (CPA) through the wall of the rodent iliac artery. The gap junction plaques constructed from Cx37 and Cx40 were abundant in the endothelium. This peptide provides inhibitory effects against subintimal hyperpolarization.)
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Cat. No.: HY-124381
CAS No.: 174008-52-7
Target:  

5-HT Receptor

Research Areas:  

Others

ML10375 is a compound that modulates 5-HT4 and 5-HT2 receptors, affects gap junction coupling in rat atrial myocytes, and regulates intracellular cAMP concentration and L-type calcium current.
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Cat. No.: HY-15204S
CAS No.: 1329837-33-3
Synonyms: SB-220453-d6
Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system .
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Cat. No.: HY-117275S1
Synonyms: Meclofenamate-13C6
Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
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Cat. No.: HY-B1320R
CAS No.: 6385-02-0
Synonyms: Meclofenamate sodium (Standard)
Meclofenamic acid (sodium) (Standard) is the analytical standard of Meclofenamic acid (sodium). This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .
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Cat. No.: HY-117275S
CAS No.: 1185072-18-7
Synonyms: Meclofenamate-d4
Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker .
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Cat. No.: HY-134110
CAS No.: 156910-29-1
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
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