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Cat. No.: HY-14584

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PQ-1

PQ-1 is a gap junction enhancer.

For research use only. We do not sell to patients.

CAS No.: 955995-48-9
Formula: C₂₁H₂₂F₃N₃O₂
Molecular Weight:405.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PQ-1 Chemical Structure

CAS No.: 955995-48-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PQ-1 is a gap junction enhancer. PQ-1 activates p44/42 MAPK, increases phosphorylated p38-MAPK, reduces Bcl-2 expression, increases the cleavage of pro-caspase-3. PQ-1 affects the Raf-MEK-ERK cascade, induces Apoptosis. PQ-1 can be used in the research of breast cancer^[1].

All p38 MAPK Isoforms :

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

All Raf Isoforms :

All MEK Isoforms :

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
T47D	IC₅₀	119 nM Compound: 1	Cell viability of human T47D cells by trypan blue exclusion assay Cell viability of human T47D cells by trypan blue exclusion assay	[PMID: 18457950]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 955995-48-9
Molecular Weight 405.41
Formula C₂₁H₂₂F₃N₃O₂
SMILES

NCCCNC1=C2C(C(C)=CC=N2)=C(OC3=CC=CC(C(F)(F)F)=C3)C(OC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shishido SN, et al. Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jan 29;17(2):178. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Purity & Documentation
References

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PQ-1

All p38 MAPK Isoforms

All Bcl-2 Family Isoforms

All Caspase Isoforms

All Raf Isoforms

All MEK Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PQ-1 Related Classifications

HY-14584 Related Classifications