79 Results for "

vascular function

" in MedChemExpress (MCE) Product Catalog:
Products (79)

79 Results for "vascular function" in MCE Product Catalog:

Adenosine (Standard)
Adenosine (Standard)
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Cat. No.: HY-B0228R
CAS No.: 58-61-7
Synonyms: Adenine riboside (Standard); D-Adenosine (Standard)
Category:  

Natural Products Microorganisms Endogenous metabolite

Target:  

Reference Standards Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite

Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
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Adenosine-13C10
Adenosine-13C10
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Cat. No.: HY-B0228S13
CAS No.: 1887761-94-5
Synonyms: Adenine riboside-13C10; D-Adenosine-13C10
Adenosine- 13C10 (Adenine riboside- 13C10; D-Adenosine- 13C10) is 13C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
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Adenosine-13C10,15N5
Adenosine-13C10,15N5
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Cat. No.: HY-B0228S9
CAS No.: 202406-75-5
Adenosine- 13C10, 15N5 is the 13C and 15N labeled Adenosine (HY-B0228) . Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
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Hydroxytyrosol acetate
Hydroxytyrosol acetate
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Cat. No.: HY-N6043
CAS No.: 69039-02-7
Category:  

Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV Estrogen Receptor/ERR

Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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Adenosine-d1
Adenosine-d1
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Cat. No.: HY-B0228S
CAS No.: 109923-50-4
Synonyms: Adenine riboside-d1; D-Adenosine-d
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .
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Hydrochlorothiazid-13C,d2
Hydrochlorothiazid-13C,d2
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Cat. No.: HY-B0252S1
CAS No.: 1190006-03-1
Synonyms: HCTZ-13C,d2
Hydrochlorothiazid- 13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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N-Feruloylserotonin
N-Feruloylserotonin
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Cat. No.: HY-118824A
CAS No.: 68573-23-9
Purity:  99.93%
Synonyms: (E/Z)-Moschamine
Category:  

Cardiovascular Disease Alkaloids Carthamus tinctorius L. Phenols Polyphenols Plants Compositae Disease Research Fields Indole Alkaloids

Target:  

Calcium Channel PDGFR ERK

N-Feruloylserotonin ((E/Z)-Moschamine) is a serotonin hydroxycinnamic acid amide. It can be isolated from a variety of plants, particularly the seeds of safflower (Carthamus tinctorius L.). N-Feruloylserotonin inhibits KCl- and 5-HT-induced elevation of intracellular [Ca 2+]i. It suppresses PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2. N-Feruloylserotonin exerts anti-inflammatory effects on aortic endothelial cells. It inhibits atherosclerotic plaque formation in apolipoprotein E-deficient mice .
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Cenupatide
Cenupatide
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Cat. No.: HY-P1615
CAS No.: 1006388-38-0
Synonyms: UPARANT
Target:  

Transmembrane Glycoprotein Formyl Peptide Receptor (FPR) VEGFR Akt STAT JNK p38 MAPK ERK NF-κB Apoptosis Integrin

연구분야:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cenupatide (UPARANT) is a uPAR and FPR antagonist with anti-angiogenic, anti-inflammatory, and vascular barrier regulatory activities, as well as high stability and resistance to enzymatic degradation in blood/plasma. Cenupatide blocks the uPAR-FPR interaction, reduces VEGF-induced phosphorylation levels of AKT, VEGFR-2, STAT3, JNK, p38 MAPK, ERK1/2, and NF-κB p65, and inhibits αvβ3 integrin activation. Cenupatide suppresses endothelial cell migration, invasion, tube formation, and angiogenic signaling pathways, restores tight junctions and blood-retinal barrier integrity, reduces pro-inflammatory marker levels, and inhibits apoptosis. Cenupatide reduces retinal neovascularization, renal fibrosis, and vascular leakage, and restores visual function in preclinical models. Cenupatide is applicable to research related to retinopathy, diabetic complications, ocular diseases, cancer, and inflammatory diseases .
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Hydroxytyrosol (Standard)
Hydroxytyrosol (Standard)
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Cat. No.: HY-N0570R
CAS No.: 10597-60-1
Synonyms: DOPET (Standard); 3,4-Dihydroxyphenethyl alcohol (Standard); 3-Hydroxytyrosol (Standard)
Category:  

Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Endogenous metabolite

Target:  

Reference Standards Apoptosis Bacterial Reactive Oxygen Species (ROS) SARS-CoV Estrogen Receptor/ERR

Hydroxytyrosol (Standard) (DOPET (Standard)) is the analytical standard of Hydroxytyrosol (HY-N0570). This product is intended for research and analytical applications. Hydroxytyrosol is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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Pegevongitide
Pegevongitide
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Cat. No.: HY-P10887
CAS No.: 2988012-71-9
Synonyms: AV-001
Target:  

Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin

연구분야:  

Cardiovascular Disease Infection Neurological Disease

Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions . Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia .
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Hydrochlorothiazide (Standard)
Hydrochlorothiazide (Standard)
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Cat. No.: HY-B0252R
CAS No.: 58-93-5
Synonyms: HCTZ (Standard)
Target:  

Reference Standards TGF-beta/Smad Potassium Channel

연구분야:  

Cardiovascular Disease Metabolic Disease Cancer

Hydrochlorothiazide (Standard) is the analytical standard of Hydrochlorothiazide. This product is intended for research and analytical applications. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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Hydrochlorothiazid-d2
Hydrochlorothiazid-d2
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Cat. No.: HY-B0252S
CAS No.: 1219798-89-6
Synonyms: HCTZ-d2
Hydrochlorothiazid-d2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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Adenosine-d13
Adenosine-d13
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Cat. No.: HY-B0228S12
Synonyms: Adenine riboside-d13; D-Adenosine-d13
Adenosine-d13 (Adenine riboside-d13; D-Adenosine-d13) is deuterium labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
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Hydrochlorothiazide-15N2,13C,d2
Hydrochlorothiazide-15N2,13C,d2
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Cat. No.: HY-B0252S3
CAS No.: 2140316-81-8
Synonyms: HCTZ-15N2,13C,d2
Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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Zofenoprilat
Zofenoprilat
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Cat. No.: HY-133829
CAS No.: 75176-37-3
Target:  

Angiotensin-converting Enzyme (ACE) NO Synthase Reactive Oxygen Species (ROS)

연구분야:  

Cardiovascular Disease

Zofenoprilat is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.7 nM. Zofenoprilat exerts cardioprotective and renoprotective effects by inhibiting angiotensin II expression and lowering blood pressure. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression. Zofenoprilat decreases TNFα-induced ROS production and protects vascular endothelial function. Zofenoprilat regulates oxidative stress-related molecules and possesses antioxidant activity. Zofenoprilat can be used in studies related to hypertension and congestive heart failure .
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Ceramide 3-d3
Ceramide 3-d3
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Cat. No.: HY-141582S
CAS No.: 1354806-91-9
Synonyms: N-Stearoyl phytosphingosine-d3
Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.
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3,5,7,3′,4′-Pentamethoxyflavone (Standard)
3,5,7,3′,4′-Pentamethoxyflavone (Standard)
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Cat. No.: HY-N7690R
CAS No.: 1247-97-8
Category:  

Flavonoids Flavones Plants Zingiberaceae

Target:  

Reference Standards Calcium Channel

3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .
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Properdistatin
Properdistatin
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Cat. No.: HY-P3996
CAS No.: 945373-85-3
Target:  

Inhibitory Antibodies

연구분야:  

Cancer

Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma .
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12(S)-HPETE
12(S)-HPETE
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Cat. No.: HY-113443
CAS No.: 71774-10-2
Target:  

AP-1

연구분야:  

Metabolic Disease

12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .
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MPO-IN-9
MPO-IN-9
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Cat. No.: HY-175985
CAS No.: 3030264-54-8
Target:  

Reactive Oxygen Species (ROS)

연구분야:  

Inflammation/Immunology

MPO-IN-9 is a selective inhibitor of myeloperoxidase (MPO), with an IC50 value of 3.9 nM. MPO-IN-9 inhibits MPO-mediated ROS production and protects NO-dependent vascular function by blocking MPO's chlorination and peroxidation cycles. MPO-IN-9 can be used for the study of diseases such as chronic kidney disease (CKD), non-alcoholic steatohepatitis (NASH) .
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