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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
Traf6
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "Traf6" in MCE Product Catalog:
Cat. No.: HY-P11001
CAS No.: 1393741-66-6
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Cat. No.: HY-RS16663
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Traf6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Traf6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23098
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Traf6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Traf6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-164670
CAS No.: 2676188-98-8
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D228 is an orally active antiinflammatory agent. D228 reduces ConA induced T lymphocyte cell proliferation (IC50: 42.85 μM) and LPS induced B lymphocyte cell proliferation (IC50: 3.15 μM). D228 is effective against inflammatory bowel disease (IBD). D228 alleviates the DSS (HY-116282C)-induced inflammation response in the IBD model by downregulating the MyD88/TRAF6/p38 signaling .
Cat. No.: HY-P11002
CAS No.: 500905-47-5
Synonyms: Antennapedia leader peptide
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Cat. No.: HY-176220
CAS No.: 3060458-90-1
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GPX4-AUTAC is a GPX4-targeting autophagy-mediated degrader (AUTAC). GPX4-AUTAC consists of an inhibitor ML162-yne (HY-153748), a degradation tag FBnG (HY-W073762) and a glycol linker (HY-W021401). GPX4-AUTAC promotes the ubiquitination of GPX4 by E3 ligase TRAF6, and enhances the binding with GPX4 and p62, leading to the selective autophagy-dependent degradation of GPX4. GPX4-AUTAC significantly induces ferroptosis and shows a potent anti-cancer activity in breast cancer cells, breast cancer-derived organoids (PDOs) and MDA-MB-231 tumor xenograft mice model, with potent synergistic effects when combined with Sulfasalazine (SAS) (HY-14655) or chemotherapy drugs (Paclitaxel (HY-B0015) or Cisplatin (HY-17394)) .
Cat. No.: HY-P7S0408
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Traf6; RING-Type E3 Ubiquitin Transferase Traf6; TNF Receptor Associated Factor 6; E3 Ubiquitin-Protein Ligase Traf6; RNF85; TNF Receptor-Associated Factor 6; RING Finger Protein 85; Interleukin-1 Signal Transducer; TNF Receptor-Associated Factor 6, E3 Ub
Species:
Human
Source:
E. coli
Cat. No.: HY-P80919A
Synonyms: Traf6; RNF85; TNF receptor-associated factor 6; E3 ubiquitin-protein ligase Traf6; Interleukin-1 signal transducer; RING finger protein 85
Cat. No.: HY-N0026R
CAS No.: 94492-24-7
Synonyms: 2'-AA (Standard)
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Dexamethasone phosphate (Standard) (Dexamethasone 21-phosphate (Standard)) is the analytical standard of Dexamethasone phosphate (HY-B1829). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).
Cat. No.: HY-110247R
CAS No.: 433249-94-6
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TRAF-STOP inhibitor 6877002 (Standard) is the analytical standard of TRAF-STOP inhibitor 6877002 (HY-110247). This product is intended for research and analytical applications. TRAF-STOP inhibitor 6877002 is a selective CD40-TRAF6 interaction inhibitor. TRAF-STOP inhibitor 6877002 exerts anti-atherosclerotic activity by blocKing the CD40-TRAF6 signaling pathway, inhibiting classical monocyte activation, leukocyte recruitment, and macrophage activation and migration. TRAF-STOP inhibitor 6877002 reduces the phosphorylation levels of signaling intermediates in the canonical NF-κB pathway .
Cat. No.: HY-184160
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Mcl1 Degrader-1 is an autophagy-targeting chimera (AUTAC) that selectively degrades the Mcl1 protein. Mcl1 Degrader-1 mediates K63 ubiquitination of Mcl1 via TRAF6/UBC13, transports it to autolysosomes for degradation through p62/SQSTM1, and activates Beclin1-dependent autophagy. Mcl1 Degrader-1 can be used in studies related to multiple myeloma and non-small cell lung cancer .
Cat. No.: HY-174520
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Human TLR8 mRNA encodes the human toll like receptor 8 (TLR8) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Cat. No.: HY-FLB1829A
CAS No.: 2392-39-4
Synonyms: Dexamethasone 21-phosphate disodium solution
Dexamethasone sodium phosphate solution is mainly composed of Dexamethasone phosphate disodium (HY-B1829A). Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) [6].
Cat. No.: HY-P71410
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V1; Ubiquitin Conjugating Enzyme E2 V1; UBE2V; CROC-1; UEV-1; CROC1; Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV1A; Traf6-Regulated IKK Activator 1 Beta Uev1A; UEV1; HCG2018358,Isoform CRA_d; DNA-Binding Protein; CIR1
Species:
Human
Source:
E. coli
Cat. No.: HY-P701489
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V1; Ubiquitin Conjugating Enzyme E2 V1; UBE2V; CROC-1; UEV-1; CROC1; Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV1A; Traf6-Regulated IKK Activator 1 Beta Uev1A; UEV1; HCG2018358,Isoform CRA_d; DNA-Binding Protein; CIR1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701501
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V1; Ubiquitin Conjugating Enzyme E2 V1; UBE2V; CROC-1; UEV-1; CROC1; Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV1A; Traf6-Regulated IKK Activator 1 Beta Uev1A; UEV1; HCG2018358,Isoform CRA_d; DNA-Binding Protein; CIR1
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
