2. Natural Products
  3. Plants
  4. Gentianaceae
  5. Gentiana macrophylla Pall.

Gentiana macrophylla Pall.

Gentiana macrophylla Pall. (9):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0481
    Roburic acid 6812-81-3 99.93%
    Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a Ki of 7.066 μM against human TNF, an IC50 of 9 μM against human COX-2, and an IC50 of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases.
    Roburic acid
  • HY-N6039
    Gentianine 439-89-4 98.0%
    Gentianine, an active metabolite of Swertiamarin, has anti-diabetic effect and anti-inflammatory property.
    Gentianine
  • HY-N17036
    Macrophylloside B 179457-67-1
    Macrophylloside B is a natural iridoid.
    Macrophylloside B
  • HY-N17090
    Macrophylloside A 179457-66-0
    Macrophylloside A is a natural iridoid.
    Macrophylloside A
  • HY-N9733
    2-Methoxyanofinic acid 179457-70-6
    2-Methoxyanofinic acid is an iridoid compound that can be found in Gentiana macrophylla.
    2-Methoxyanofinic acid
  • HY-N3861
    Erythrocentaurin 50276-98-7
    Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor.
    Erythrocentaurin
  • HY-N3860
    Erythrocentauric acid 90921-13-4
    Erythrocentauric acid is a Coumarins product that can be isolated from the roots of Gentiana macrophylla..
    Erythrocentauric acid
  • HY-N13480
    Macrophylloside D 179457-69-3
    Macrophylloside D is a natural product.
    Macrophylloside D
  • HY-N0481R
    Roburic acid (Standard) 6812-81-3
    Roburic acid (Standard) is the analytical standard of Roburic acid. This product is intended for research and analytical applications. Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a Ki of 7.066 μM against human TNF, an IC50 of 9 μM against human COX-2, and an IC50 of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases.
    Roburic acid (Standard)