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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
DNA-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "DNA-dependent" in MCE Product Catalog:
Cat. No.: HY-163016
CAS No.: 2447106-79-6
Target:
Research Areas:
RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .
Cat. No.: HY-17025S1
Synonyms: Ansamycin-d6; LM-427-d6
Cat. No.: HY-146566
CAS No.: 3034675-75-4
DNA-PK-IN-9 (compound YK6) is a potent DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 10.47 nM. DNA-PK-IN-9 can be used for researching anticancer .
Cat. No.: HY-164539
CAS No.: 2231800-32-9
TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC .
Cat. No.: HY-134033A
Synonyms: 2'-Fluoro dATP sodium
Target:
Research Areas:
2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP (HY-B2176). 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM .
Cat. No.: HY-13234R
CAS No.: 80621-81-4
Rifaximin (Standard) is the analytical standard of Rifaximin. This product is intended for research and analytical applications. Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL) .
Cat. No.: HY-114923
CAS No.: 688036-19-3
SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy .
Cat. No.: HY-B1907R
CAS No.: 14897-39-3
Synonyms: Rifamycin SV sodium (Standard)
Target:
Cat. No.: HY-105099R
CAS No.: 129791-92-0
Synonyms: KRM-1648 (Standard); ABI-1648 (Standard)
Research Areas:
Rifalazil (Standard) is the analytical standard of Rifalazil. This product is intended for research and analytical applications. Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
Cat. No.: HY-137673A
CAS No.: 1514900-83-4
Target:
Research Areas:
2'-Deoxy-NAD+ sodium is a noncompetitive NAD+ inhibitor with a Ki of 32 μM. 2'-Deoxy-NAD+ sodium can be utilized as a substrate to study the ADP-ribosyl transfer reaction .
Cat. No.: HY-122176
CAS No.: 503465-21-2
Target:
Research Areas:
NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 >10 μM. NU-7107 is applicable for cancer research .
Cat. No.: HY-187604
CAS No.: 113303-81-4
Research Areas:
CGP 4832 is a Rifamycin S (HY-125365) derivative and Antibacterial agent. CGP 4832 inhibits DNA-dependent transcription through DNA-dependent RNA polymerase. CGP 4832 exhibits activity against Gram-positive bacteria comparable to Rifampicin (HY-B0272), but is more potent against certain Gram-negative bacterial species, such as Escherichia coli ETH 2018 (MIC 0.01 µg/mL) and Salmonella AX 5 (MIC 0.5 µg/mL). CGP 4832 can be used for research on Gram-negative bacterial infections .
Cat. No.: HY-P704188
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZBP1; Z-DNA Binding Protein 1; alias:C20orf183; DLM1; DAI; Tumor Stroma And Activated Macrophage Protein DLM-1; Z-DNA-Binding Protein 1; DLM-1; DNA-dependent Activator Of IRFs; DJ718J7.3; DNA-dependent Activator Of IFN-Regulatory Factors; Chromosome 20 Op
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
