2. Others PI3K/Akt/mTOR Cell Cycle/DNA Damage
  3. Drug Derivative DNA-PK
  4. NU-7107

NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 >10 μM. NU-7107 is applicable for cancer research.

For research use only. We do not sell to patients.

NU-7107

NU-7107 Chemical Structure

CAS No. : 503465-21-2

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NU-7107 Related Antibodies

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Description

NU-7107 is a derivative of NU7026 (HY-15719) and a DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 >10 μM. NU-7107 is applicable for cancer research[1].

In Vitro

NU7107 weakly inhibits DNA-PK with an IC50 of >10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NU-7107 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax T1/2 Vd
Mice[1] 20 mg/kg i.p. 10390 nM 0.25 h 0.79 h 0.12 L
In Vivo

NU-7107 (20 mg/kg; i.p.; single administration) exhibits significantly improved in vivo pharmacokinetic properties compared with NU7026 in female BALB/c mice, with a 4-fold lower plasma clearance rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female)[1]
Dosage: 20 mg/kg
Administration: i.p.; single dose
Result: Reached a maximum plasma concentration (Cmax) of 10390 nmol/L.
Reached time to maximum concentration (Tmax) of 0.25 h.
Achieved area under the concentration vs time curve (AUC last) of 12165 nmol·h/L.
Had a terminal half-life (t1/2) of 0.79 h.
Had plasma clearance (CI obs.) of 0.11 L/h.
Had volume of distribution (Vd) of 0.12 L.
Remained detectable in plasma 6 hours post-administration.
Exhibited plasma clearance four-fold slower than that of NU7026.
Molecular Weight

309.37

Formula

C18H19N3O2
CAS No.
SMILES

O=C1N2C(C=3C(C=C2)=CC=CC3)=NC(=C1)N4C[C@H](C)O[C@H](C)C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NU-7107 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NU-7107503465-21-2NU7107NU 7107Drug DerivativeDNA-PKDrug derivativeDNA-dependent protein kinasefemale BALB/c miceInhibitorinhibitorinhibit

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