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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
DNA-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "DNA-dependent" in MCE Product Catalog:
Cat. No.: HY-P704184
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZBP1; Z-DNA Binding Protein 1; alias:C20orf183; DLM1; DAI; Tumor Stroma And Activated Macrophage Protein DLM-1; Z-DNA-Binding Protein 1; DLM-1; DNA-dependent Activator Of IRFs; DJ718J7.3; DNA-dependent Activator Of IFN-Regulatory Factors; Chromosome 20 Op
Species:
Mouse
Source:
HEK293
Cat. No.: HY-165401
CAS No.: 22785-18-8
Target:
Research Areas:
SC 19886 is an inhibitor of Aldosterone (HY-113313) synthesis. SC 19886 blocks Aldosterone-induced DNA-dependent RNA synthesis. SC 19886 can be used in studies related to primary aldosteronism [1] [2].
Cat. No.: HY-122226
CAS No.: 404011-02-5
IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC50 of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of DNA-PKcs and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma .
Cat. No.: HY-181848
DNA-PK-IN-16 is an orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 of 10.2 nM. DNA-PK-IN-16 induces the upregulation of γH2A.X, a biomarker of DNA double-strand breaks. DNA-PK-IN-16 exhibits antiproliferative activity in various cancer cell lines. DNA-PK-IN-16 enhances the infiltration of CD8 + T cells in tumor tissues through synergistic action with anti-PD-L1 monoclonal antibody. DNA-PK-IN-16 is applicable for cancer research .
Cat. No.: HY-P75675
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CIB2; DNA-dependent Protein Kinase Catalytic Subunit-Interacting Protein 2; Prev. DFNB48; Deafness, Autosomal Recessive 48; Prev. USH1J; Kinase Interacting Protein 2; KIP2; Kinase-Interacting Protein 2; Calcium And Integrin-Binding Family Member 2; KIP 2
Species:
Human
Source:
E. coli
Cat. No.: HY-P75675A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CIB2; DNA-dependent Protein Kinase Catalytic Subunit-Interacting Protein 2; Prev. DFNB48; Deafness, Autosomal Recessive 48; Prev. USH1J; Kinase Interacting Protein 2; KIP2; Kinase-Interacting Protein 2; Calcium And Integrin-Binding Family Member 2; KIP 2
Species:
Human
Source:
E. coli
Cat. No.: HY-134360A
Synonyms: (y-AmNS)-ATP sodium
Target:
Research Areas:
ATP-1-Aminonaphthalene-5-sulfonate ((y-AmNS)-ATP) sodium is a fluorescent analog of ATP (HY-B2176). ATP-1-Aminonaphthalene-5-sulfonate is a substrate for DNA-dependent RNA polymerase and valyl t-RNA synthetase (Ex/Em = 320/460 nm) .
Cat. No.: HY-134320A
Synonyms: 8-Azidoadenosine 5'-triphosphate tetrasodium; 8-N3-ATP tetrasodium
Target:
Research Areas:
8-Azido-ATP (8-Azidoadenosine 5'-triphosphate) tetrasodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP tetrasodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP tetrasodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
Cat. No.: HY-101570R
CAS No.: 1637542-33-6
Synonyms: Peposertib (Standard); M3814 (Standard)
Target:
Research Areas:
Nedisertib (Standard) is the analytical standard of Nedisertib (HY-101570). This product is intended for research and analytical applications. Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .
Cat. No.: HY-L044
593 compounds
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.
MCE offers a unique collection of 593 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).
Cat. No.: HY-131319
CAS No.: 35225-13-9
Rifamycin AF-013 is a derivative of Rifamycin (HY-B1907). Rifamycin AF-013 inhibits DNA polymerase γ by competing with dTTP and template primers for binding. Rifamycin AF-013 exhibits inhibitory activity against Rifampicin (HY-B0272)-resistant RNA polymerase. Rifamycin AF-013 inhibits non-polymerase enzymes including glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and Alkaline phosphatase. Rifamycin AF-013 can be used in research related to Rifampicin-resistant bacterial infections and Ehrlich ascites tumors .
Cat. No.: HY-P85597
Synonyms: 5''-deoxyribose-5-phosphate lyase Ku70; 5''-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70; Ku70 DNA binding component of DNA-dependent proteinkinase complex; thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD; Ku antigen; Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; Thyroid-lupus autoantigen; TLAA; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; XRCC 6; XRCC6; XRCC6_HUMAN.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
