Rifamycin AF-013
Rifamycin AF-013 is a derivative of Rifamycin (HY-B1907). Rifamycin AF-013 inhibits DNA polymerase γ by competing with dTTP and template primers for binding. Rifamycin AF-013 exhibits inhibitory activity against Rifampicin (HY-B0272)-resistant RNA polymerase. Rifamycin AF-013 inhibits non-polymerase enzymes including glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and Alkaline phosphatase. Rifamycin AF-013 can be used in research related to Rifampicin-resistant bacterial infections and Ehrlich ascites tumors.
For research use only. We do not sell to patients.
- CAS No.: 35225-13-9
- Formula: C46H64N2O13
- Molecular Weight:853.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
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RNA Polymerase |
DNA Polymerase |
In Vitro
Rifamycin AF-013 (10 μg/mL) inactivation of Rifampicin (HY-B0272)-resistant E. coli DNA-dependent RNA polymerase is protected against by Bovine Serum Albumin, restoring enzyme activity to 60-65% of control levels[1].
Rifamycin AF-013 (10-100 μg/mL) inhibits non-polymerase enzymes including GOT, GPT, and alkaline phosphatase in a concentration-dependent manner, with GPT showing the highest sensitivity and alkaline phosphatase showing the lowest sensitivity at tested concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 35225-13-9
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Molecular Weight 853.01
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Formula C46H64N2O13
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SMILES
O=C(C)O[C@@H]1[C@@H]([C@H](/C=C/O[C@@]2(C)OC3=C(C4=C(C(/C=N/OCCCCCCCC)=C(C(O)=C4C(O)=C3C)NC(/C(C)=C/C=C/[C@@H]([C@@H]([C@H]([C@H]([C@H]1C)O)C)O)C)=O)O)C2=O)OC)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rifamycin AF-013 Related Classifications
HY-131319 Related Classifications
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Keywords
- Rifamycin AF-013
- 35225-13-9
- Rifamycin AF013
- Rifamycin AF 013
- DNA/RNA Synthesis
- Aminotransferases (Transaminases)
- Phosphatase
- Drug Derivative
- ehrlich ascites tumor
- rifampicin-resistant E. coli
- DNA polymerase γ
- B. subtilis DNA
- GOT
- bovine serum albumin
- rifampicin-resistant DNA-dependent RNA polymerase
- rifampicin-resistant bacterial infection
- DNA polymerase α
- wild-type DNA-dependent RNA polymerase
- Inhibitor
- inhibitor
- inhibit