![1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea](https://file.medchemexpress.com/product_pic/hy-w046841.gif "Click to View 1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
eIF2alpha
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "eIF2alpha" in MCE Product Catalog:
Cat. No.: HY-159494
Target:
Research Areas:
PROTAC sEH degrader-1 is a PROTAC degrader targeting soluble epoxide hydrolase (sEH) with a DC50 of 0.5 nM, and it also possesses sEH inhibitory activity. PROTAC sEH degrader-1 has an IC50 of 3.8 nM against human sEH and an IC50 of 210 nM against mouse sEH. PROTAC sEH degrader-1 relies on the ubiquitin-proteasome system to achieve target protein degradation, and it selectively degrades cytoplasmic sEH. PROTAC sEH degrader-1 rapidly reduces endoplasmic reticulum stress in cells, downregulates the phosphorylation levels of IRE1α, PERK and eIF2α, enhances cell viability, and alleviates Thapsigargin (HY-13433)-induced apoptosis. PROTAC sEH degrader-1 effectively degrades sEH in mouse liver and brown adipose tissue. PROTAC sEH degrader-1 can be used in studies related to metabolic disorders and inflammation .
Cat. No.: HY-P702962
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: eIF2S1; Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa; Prev. eIF2; eIF2-Alpha; eIF-2alpha; eIF-2A; eIF2A; Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD ); Eukaryotic Translation Initiation Factor 2 Subunit 1; eIF-
Species:
Human
Source:
E. coli
Cat. No.: HY-P705590
Synonyms: eIF2AK4; Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4; Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4; Non-Specific Serine/Threonine Protein Kinase; GCN2; General Control Nonderepressible 2; KIAA1338; GCN2 eIF2alpha Kinase; eIF-2-A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-RS04254
Target:
Research Areas:
EIF2S1 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21851
Target:
Research Areas:
Eif2s1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Eif2s1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-184599
Research Areas:
OICR-403184 is a selective RNA-dependent protein kinase (PKR) inhibitor with limited brain penetration, with an IC50 of 263 nM. OICR-403184 blocks the phosphorylation of eIF2α downstream of PKR. OICR-403184 is applicable to the research of inflammatory bowel disease .
Cat. No.: HY-12495R
CAS No.: 1597403-47-8
Target:
Research Areas:
ISRIB (trans-isomer) (Standard) is the analytical standard of ISRIB (trans-isomer) (HY-12495). This product is intended for research and analytical applications. ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).
Cat. No.: HY-183704
Research Areas:
ISR activator-5 is an eIF2B modulator and integrated stress response (ISR) activator. ISR activator-5 stabilises the inactive I-state of eIF2B, inhibits protein synthesis, and activates canonical ISR pathways without inducing eIF2α phosphorylation. ISR activator-5 can be used for the research of cancer, neurologic and metabolic disorders .
Cat. No.: HY-181959
CAS No.: 2752441-61-3
Research Areas:
APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a Ki of 4.39 nM and a Kd of 2.9 nM. APL-4098 reduces the phosphorylation level of eIF2α and the expression level of ATF4. APL-4098 impairs mitochondrial function and exerts cytotoxic effects on primary acute myeloid leukemia cells. APL-4098 is applicable to research related to acute myeloid leukemia .
Cat. No.: HY-111022R
CAS No.: 951441-04-6
Synonyms: Sephin1 (Standard); IFB-088 (Standard)
Target:
Research Areas:
Icerguastat (Standard) is the analytical standard of Icerguastat (HY-111022). This product is intended for research and analytical applications. Icerguastat (Sephin1), a derivative of Guanabenz lacKing the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect [2] .
Cat. No.: HY-W046841
CAS No.: 3824-74-6
Research Areas:
1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea is a potent activator of eIF2α kinase heme regulated inhibitor. 1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea reduces the abundance of eIF2·GTP·tRNAi Met ternary complex. 1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea inhibits cancer cell proliferation .
Cat. No.: HY-181087
Research Areas:
Anticancer agent 296 is a potent anticancer agent that activates the PERK-eIF2α-CHOP signaling pathway to induce endoplasmic reticulum stress, thereby regulating caspase and Bcl-2 family proteins, ultimately leading to apoptosis. Anticancer agent 296 increases intracellular levels of reactive oxygen species (ROS), reduces mitochondrial membrane potential, and promotes Ca 2+ release. Anticancer agent 296 suppresses cell colony formation and S-phase cell proliferation, and induces autophagy. Anticancer agent 296 is applicable for research on non-small cell lung cancer (NSCLC) .
Cat. No.: HY-186313
CAS No.: 3079914-21-6
Research Areas:
PTC-IN-1 is a human ribosomal peptidyl transferase center (PTC) inhibitor. PTC-IN-1 forms stable interactions with 28S rRNA and undergoes steric-hindrance electrostatic interactions with nascent polypeptide chains, thereby inducing context-dependent translation arrest. PTC-IN-1 activates the ribotoxic stress response through phosphorylation of p46 and p54 JNK, triggers ribosome collisions, and activates the integrated stress response via phosphorylation of eIF2α. PTC-IN-1 inhibits the proliferation of cancer cells. PTC-IN-1 can be used in the research of triple-negative breast cancer, prostate cancer, colorectal cancer .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
