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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
rhythms
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "rhythms" in MCE Product Catalog:
Cat. No.: HY-131947
CAS No.: 343263-95-6
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DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively .
Cat. No.: HY-171278
CAS No.: 1095750-94-9
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Casein kinase 1δ-IN-28 (Compound 4) is the inhibitor for CK1ε with an IC50 of 0.0146 μM. Casein kinase 1δ-IN-28 exhibits a metabolite rate in human liver microsomes of 52% .
Cat. No.: HY-19117
CAS No.: 113241-47-7
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BRL-32872 is a potent human ether-a-go-go-related gene (hERG) potassium channel blocker (IC50=241 nM in isolated cardiomyocytes; 19.8 nM in HEK293 cells). BRL-32872 is promising for research of cardiac arrhythmias (e.g., atrial/ventricular rhythms) .
Cat. No.: HY-B1812S2
CAS No.: 362049-43-2
Synonyms: 1,2-Dimethoxybenzene-d10
Cat. No.: HY-170862
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E3 Ligase Ligand-linker Conjugate 163 is the E3 ligase ligand (E3 ligase Ligand 58, HY-170861)-linker conjugate part of AH078 (HY-170859). AH078 is a PROTAC that targets the degradation of CK1δ and CK1ε, and can be used for research related to circadian rhythm disorders .
Cat. No.: HY-100813R
CAS No.: 125464-42-8
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Saclofen (Standard) is the analytical standard of Saclofen.
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Cat. No.: HY-B1812S4
CAS No.: 3047059-94-6
Synonyms: 1,2-Dimethoxybenzene-d2-1
Cat. No.: HY-120355
CAS No.: 1446770-54-2
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AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect .
Cat. No.: HY-P2061
CAS No.: 128140-12-5
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Cat. No.: HY-162336
CAS No.: 2765264-27-3
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Casein kinase 1δ-IN-15 is an inhibitor for casein kinase 1 (CK1δ), with an IC50 of 0.045 μM .
Cat. No.: HY-P10290
CAS No.: 99575-89-0
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Cat. No.: HY-14197AR
CAS No.: 17780-75-5
Synonyms: M&B 9302 hydrochloride (Standard)
Clorgyline hydrochloride (Standard) (M&B 9302 hydrochloride (Standard)) is the analytical standard of Clorgyline hydrochloride (HY-14197A). This product is intended for research and analytical applications. Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .
Cat. No.: HY-179514
CAS No.: 3092129-97-7
Synonyms: Gala-SR1078
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Gala-SR (Gala-SR1078) is an RORα agonist. Gala-SR ameliorates rhythm disorders by enhancing the amplitude of the circadian rhythm. Gala-SR can be used for the study of periodontitis .
Cat. No.: HY-156156
CAS No.: 2248752-25-0
Synonyms: Z1480758218; ZINC000157673384
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UCSF3384 (Z1480758218) is a selective, blood-brain barrier-permeable MT1 inverse agonist, with an EC50 of 21 nM for hMT1. UCSF3384 selectively elevates basal cAMP levels. UCSF3384 delays circadian rhythm resetting and advances the onset of wheel-running activity rhythm in Mus musculus. UCSF3384 is applicable to research related to circadian rhythm disorders .
Cat. No.: HY-14415R
CAS No.: 1254944-66-5
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SR8278 (Standard) is the analytical standard of SR8278 (HY-14415). This product is intended for research and analytical applications. SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease .
Cat. No.: HY-105439A
CAS No.: 68379-03-3
Synonyms: LY 150378
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Clofilium phosphate (LY 150378) is an antiarrhythmic/antifibrillatory agent. Clofilium phosphate significantly prolongs the action potential duration and effective refractory period of canine cardiac Purkinje fibers, increases the ventricular fibrillation threshold, reduces the risk of reentrant arrhythmias, and enables spontaneous conversion of some ventricular fibrillation episodes to sinus rhythm. Clofilium phosphate is applicable to research related to ventricular fibrillation, arrhythmias, and ventricular tachyarrhythmias .
Cat. No.: HY-P11105
CAS No.: 1202582-76-0
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Cat. No.: HY-104064R
CAS No.: 1430208-73-3
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1A-116 (Standard) is the analytical standard of 1A-116 (HY-104064). This product is intended for research and analytical applications. 1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo .
Cat. No.: HY-108015R
CAS No.: 1357266-05-7
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RO5263397 (Standard) is the analytical standard of RO5263397 (HY-108015). This product is intended for research and analytical applications. RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
