Clofilium phosphate

Clofilium phosphate selectively prolongs the action potential duration and effective refractory period of Purkinje fibers in normal dogs^[1].
Clofilium phosphate (30-100 nM) prolongs the action potential duration of canine papillary muscle and ventricular free wall cells, but exerts no effect on the APD of atrial muscle at the tested concentrations^[1].
Clofilium phosphate (30-1000 nM; for at least 1 h) selectively prolongs the action potential duration and refractory period of isolated normal canine Purkinje fibers, without significantly altering membrane responsiveness, conduction velocity, or diastolic depolarization rate; its APD-prolonging effect is more pronounced under conditions of longer basic cycle lengths and in depolarized fibers at higher concentrations^[2].
Clofilium phosphate (0.01-10 μM; 30 min) potently prolongs the APD₉₅ of isolated canine cardiac Purkinje fibers, with a C₂₀APD₉₅ value of 0.26 μM, and produces a maximum 39 ± 8% increase in APD₉₅ at 10 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.