68379-03-3
Chemical Structure
Clofilium phosphate
Synonym(s): LY 150378
- CAS No.: 68379-03-3
- Formula:C21H39ClNO4P
- Molecular Weight:435.97
IUPAC Name: N-(4-(4-chlorophenyl)butyl)-N,N-diethylheptan-1-aminium dihydrogen phosphate
InChIKey: HBLQZEWZVJXHKQ-UHFFFAOYSA-M
SMILES: O=P([O-])(O)O.ClC1=CC=C(C=C1)CCCC[N+](CC)(CC)CCCCCCC
Biological Activity: Clofilium phosphate (LY 150378) is an antiarrhythmic/antifibrillatory agent. Clofilium phosphate significantly prolongs the action potential duration and effective refractory period of canine cardiac Purkinje fibers, increases the ventricular fibrillation threshold, reduces the risk of reentrant arrhythmias, and enables spontaneous conversion of some ventricular fibrillation episodes to sinus rhythm. Clofilium phosphate is applicable to research related to ventricular fibrillation, arrhythmias, and ventricular tachyarrhythmias[1][2][3].
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Clofilium phosphate | Clofilium phosphate (LY 150378) is an antiarrhythmic/antifibrillatory agent. Clofilium phosphate significantly prolongs the action potential duration and effective refractory period of canine cardiac Purkinje fibers, increases the ventricular fibrillation threshold, reduces the risk of reentrant arrhythmias, and enables spontaneous conversion of some ventricular fibrillation episodes to sinus rhythm. Clofilium phosphate is applicable to research related to ventricular fibrillation, arrhythmias, and ventricular tachyarrhythmias. | |||||||||||||||||||||
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- [1]. Steinberg M I, et al. Clofilium1--a new antifibrillatory agent that selectively increases cellular refractoriness. Life Sciences, 1979, 25(16): 1397-1406.
- [2]. Steinberg MI, et al. Cellular electrophysiology of clofilium, a new antifibrillatory agent, in normal and ischemic canine Purkinje fibers. J Cardiovasc Pharmacol. 1981;3(4):881-895. [Content Brief]
- [3]. Lis R, et al. Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds. J Med Chem. 1987 Apr;30(4):696-704. [Content Brief]
Keywords
