2248752-25-0
2248752-25-0
Chemical Structure
UCSF3384
Synonym(s): Z1480758218; ZINC000157673384
- CAS No.: 2248752-25-0
- Formula:C18H20N4
- Molecular Weight:292.38
InChIKey: GXZIJEFRHJOZBW-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(CNC2=CC=CC(C3=NC=NN3)=C2)C=C1)C
Biological Activity: UCSF3384 (Z1480758218) is a selective, blood-brain barrier-permeable MT1 inverse agonist, with an EC50 of 21 nM for hMT1. UCSF3384 selectively elevates basal cAMP levels. UCSF3384 delays circadian rhythm resetting and advances the onset of wheel-running activity rhythm in Mus musculus. UCSF3384 is applicable to research related to circadian rhythm disorders[1][2].
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UCSF3384 | UCSF3384 (Z1480758218) is a selective, blood-brain barrier-permeable MT1 inverse agonist, with an EC50 of 21 nM for hMT1. UCSF3384 selectively elevates basal cAMP levels. UCSF3384 delays circadian rhythm resetting and advances the onset of wheel-running activity rhythm in Mus musculus. UCSF3384 is applicable to research related to circadian rhythm disorders. | |||||||||||||||||||||
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References
- [1]. Bedini A, et al. Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey. Journal of pineal research. 2024 May;76(4):e12953.
- [2]. Stein RM, et al. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature. 2020 Mar;579(7800):609-614. [Content Brief]
