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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
118 Results for "
hypothalamic
" in MedChemExpress (MCE) Product Catalog:
Products (118)
118 Results for "hypothalamic" in MCE Product Catalog:
Cat. No.: HY-117787
CAS No.: 1390641-90-3
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TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression .
Cat. No.: HY-P1303
CAS No.: 210978-19-1
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Cat. No.: HY-14811A
CAS No.: 529511-79-3
Synonyms: ZGN-440 hemioxalate; ZGN-433 hemioxalate; CDK732 hemioxalate
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Beloranib (ZGN-440; CKD-732 free base) hemioxalate is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib hemioxalate blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib hemioxalate significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib hemioxalate also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib hemioxalate can be used in research on obesity and hypothalamic obesity .
Cat. No.: HY-P3069
CAS No.: 114882-65-4
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Cat. No.: HY-P1298
CAS No.: 74434-59-6
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Sauvagine is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine can be used for research on central nervous system and blood diseases .
Cat. No.: HY-P0089
CAS No.: 83930-13-6
Synonyms: Growth Hormone Releasing Factor human; Somatorelin (1-44) amide (human)
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Cat. No.: HY-P3687
CAS No.: 83930-34-1
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Cat. No.: HY-P3683
CAS No.: 158535-55-8
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Cat. No.: HY-179131
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TN-783 is an orally active, brain-penetrant NLRP3 (IC50 = 19.3 nM) inhibitor. TN-783 enhances the effects of the GLP-1 receptor agonist semaglutide. TN-783 requires sustained targeted action, not permanent metabolic remodeling. TN-783 can be used for the study of obesity .
Cat. No.: HY-P3539
CAS No.: 196109-31-6
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Cat. No.: HY-P3641
CAS No.: 374675-18-0
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Cat. No.: HY-A0287S
CAS No.: 1346606-66-3
Synonyms: Clomifene-d5 hydrochloride; (Z/E)-Enclomiphene-d5 hydrochloride; (Z/E)-Enclomifene-d5 hydrochloride
Cat. No.: HY-125784A
CAS No.: 56287-63-9
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(R)-Viloxazine hydrochloride is the less active R-isomer of Viloxazine hydrochloride (HY-125784). (R)-Viloxazine hydrochloride can be used in the research of depression .
Cat. No.: HY-117965
CAS No.: 1400902-13-7
Synonyms: CORT 118335
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Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders .
Cat. No.: HY-W583271
CAS No.: 119700-81-1
Cat. No.: HY-P2277
CAS No.: 569364-13-2
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Cat. No.: HY-P1905
CAS No.: 47922-48-5
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Cat. No.: HY-123181
CAS No.: 633317-53-0
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MK-0916 is a HSD1 inhibitor. MK-0916 produces mechanism-based activation of the hypothalamic-pituitary-adrenal axis. MK-0916 can be used in the research of type 2 diabetes and metabolic syndromes .
Cat. No.: HY-P4815
CAS No.: 423206-00-2
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Cat. No.: HY-179132
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TN-101 is an orally active NLRP3 inhibitor (IC50 = 29.8 nM). TN-101 can be used for the study of obesity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
