1390641-90-3
1390641-90-3
Chemical Structure
TUG-905
- CAS No.: 1390641-90-3
- Formula:C27H30FNO5S
- Molecular Weight:499.59
IUPAC Name: 3-(2-fluoro-4-(((2'-methyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)propanoic acid
InChIKey: ODIHLEYTPVYAPY-UHFFFAOYSA-N
SMILES: O=C(CCC1=CC=C(C=C1F)NCC2=CC(C3=CC=C(C=C3C)OCCCS(=O)(C)=O)=CC=C2)O
Biological Activity: TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
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TUG-905 | TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression. | |||||||||||||||||||||
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References
- [1]. Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. [Content Brief]
- [2]. Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047. [Content Brief]
Keywords
