Kisspeptin 13
Based on 1 publication(s) in Google Scholar
Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 374675-18-0
- 화학식: C78H107N21O18
- 분자량:1626.81
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Kisspeptin 13
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
22.8 nM
Compound: 13-mer, metastin-13
|
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
|
[PMID: 17266198] |
| HEK293 | EC50 |
33 nM
Compound: Y4A
|
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
Activity at metastin receptor expressed in HEK293 cells by measuring calcium release
|
[PMID: 17266198] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Swiss mice with memory impairment induced by A-beta[1]
-
Dosage:2 μg/side
-
Administration:Intracerebroventricular administration; 2 μg/side; once
-
Result:Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54.
Chemical Information
-
CAS No. 374675-18-0
-
분자량 1626.81
-
화학식 C78H107N21O18
-
Sequence
Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
-
Sequence Shortening
LPNYNWNSFGLRF-NH2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
순도&문서
References
[1]. Jiang JH, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 Sep;123:187-95. [Content Brief]
[2]. Silvestre RA, et al., Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol. 2008 Feb;196(2):283-90. [Content Brief]
[3]. Csabafi K, et al., Effects of kisspeptin-13 on the hypothalamic-pituitary-adrenal axis, thermoregulation, anxiety and locomotor activity in rats. Behav Brain Res. 2013 Mar 15;241:56-61. [Content Brief]
[4]. Tanaka M, et al., Neurotransmissions of antidepressant-like effects of kisspeptin-13. Regul Pept. 2013 Jan 10;180:1-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kisspeptin 13 Related Classifications
HY-P3641 Related Classifications
Powered by Bioz