1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Mineralocorticoid Receptor
  3. Miricorilant

Miricorilant (Synonyms: CORT 118335)

Cat. No.: HY-117965
Handling Instructions

Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders.

For research use only. We do not sell to patients.

Miricorilant Chemical Structure

Miricorilant Chemical Structure

CAS No. : 1400902-13-7

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Description

Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders[1].

IC50 & Target

Glucocorticoid/Mineralocorticoid[1]

In Vivo

CORT 118335 (3-30 mg/kg) potently suppresses endocrine responses to two different stressors (restraint and FST) in male rats[1].

Animal Model: Male Sprague-Dawley rats (≈250 g)[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Subcutaneously (s.c.); five days.
Result: 30 mg/kg had lower corticosterone responses relative to 10 mg/kg at 15 and 30 min time points.
Molecular Weight

428.45

Formula

C₂₄H₂₃F₃N₂O₂

CAS No.

1400902-13-7

SMILES

O=C1NC(C(CC2=CC=CC(C(F)(F)F)=C2)=C(N1)[[email protected]]3CC[[email protected]@H](CC3)C4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MiricorilantCORT 118335CORT118335CORT-118335Glucocorticoid ReceptorMineralocorticoid Receptorglucocorticoidmineralocorticoidhypothalamicpituitary,adrenalHPAaxisInhibitorinhibitorinhibit

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