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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
117 Results for "
RNA+binding
" in MedChemExpress (MCE) Product Catalog:
Products (117)
117 Results for "RNA+binding" in MCE Product Catalog:
Cat. No.: HY-183981
Target:
Research Areas:
RNA binder 4 is an RNA-binding agent that can be used for the synthesis of MJ-NR-27 (HY-183980). MJ-NR-27 is a bifunctional ribonuclease-targeting chimera (RIBOTAC) small molecule that targets NRAS mRNA containing a G-quadruplex structure, and it can be used in cancer research .
Cat. No.: HY-174590
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.
Cat. No.: HY-L917
5,619 compounds
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs.
MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.
Cat. No.: HY-P83061
Synonyms: CELF1; BRUNOL2; CUGBP; CUGBP1; NAB50; CUGBP Elav-like family member 1; CELF-1; 50 kDa nuclear polyadenylated RNA-binding protein; Bruno-like protein 2; CUG triplet repeat RNA-binding protein 1; CUG-BP1; CUG-BP- and ETR-3-like factor 1; Dead
Cat. No.: HY-P700506
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF3G; EIF-3 RNA-Binding Subunit; Prev. EIF3S4; EIF3 P44; Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit; EIF3 P42; EIF3-Delta; EIF3g; EIF3-P44; Eukaryotic Translation Initiation Factor 3 Subunit P42; Eukaryotic Translation Initiation Fact
Species:
Human
Source:
E. coli
Cat. No.: HY-P705436
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TIA1; TIA1 Cytotoxic Granule-Associated RNA-Binding Protein; TIA1 Cytotoxic Granule Associated RNA Binding Protein; P40-TIA-1 (Containing P15-TIA-1); T-Cell-Restricted Intracellular Antigen-1; Alternative Protein TIA1; TIA-1; P40-TIA-1; Cytotoxic Granule
Species:
Human
Source:
E. coli
Cat. No.: HY-P71612
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RBM14; SYT-Interacting Protein; RNA Binding Motif Protein 14; Paraspeckle Protein 2; SIP; DKFZp779J0927; RNA-Binding Protein 14; PSP2; SYTIP1; Transmembrane Protein 137; COAA; SYT Interacting Protein; RRM-Containing Coactivator Activator/Modulator; Coacti
Species:
Human
Source:
E. coli
Cat. No.: HY-108466R
CAS No.: 37854-59-4
Target:
Research Areas:
Ro 08-2750 (Standard) is the analytical standard of Ro 08-2750 (HY-108466). This product is intended for research and analytical applications. Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA . Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM .
Cat. No.: HY-180188
Target:
Research Areas:
F1-ispinesib is a heterobifunctional F1-autophagy degrader, composed of an RNA-binding fragment (F1) and the LC3B ligand Ispinesib (HY-50759). F1-ispinesib induces degradation of COL15A1 mRNA via an LC3B-dependent macroautophagy mechanism. F1-ispinesib inhibits cell proliferation and enhances migration of human aortic smooth muscle cells .
Cat. No.: HY-P87370
Synonyms: 44kDa antibody; Anti EIF3S4 antibody; eIF 3 delta antibody; eIF 3 RNA binding subunit antibody; eIF-3 RNA-binding subunit antibody; eIF-3-delta antibody; eIF3 delta antibody; eIF3 p42 antibody; eIF3 p44 antibody; eIF3g antibody
Cat. No.: HY-P82093
Synonyms: SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein
Cat. No.: HY-P704522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIN28A; Zinc Finger CCHC Domain-Containing Protein 1; Prev. LIN28; FLJ12457; ZCCHC1; Lin-28A; CSDD1; Zinc Finger, CCHC Domain Containing 1; Lin-28 Homolog A; Lin-28 Homolog (C. Elegans); LIN-28; RNA-Binding Protein LIN-28; Lin-28 RNA Binding Posttranscrip
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
