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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
149 Results for "
apps
" in MedChemExpress (MCE) Product Catalog:
Products (149)
149 Results for "apps" in MCE Product Catalog:
Art. -Nr.: HY-P1378
CAS. Nr.: 134500-80-4
Target:
Forschungsgebiete:
Art. -Nr.: HY-176271
CAS. Nr.: 3069915-36-9
Target:
Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β
Forschungsgebiete:
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.
Art. -Nr.: HY-P1894A
Target:
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Art. -Nr.: HY-N12249
CAS. Nr.: 145987-74-2
Art. -Nr.: HY-177646A
Synonyms: ALN-APP sodium
Forschungsgebiete:
Mivelsiran (ALN-APP) sodium is an siRNA targeting the β-amyloid precursor protein (APP). Mivelsiran sodium induces sequence-specific degradation of APP mRNA via RNA interference, thereby reducing the levels of APP protein and downstream amyloid cleavage products. Mivelsiran sodium reduces β-amyloid protein levels in the brain, alleviates neuroinflammation, and attenuates microglial proliferation. Mivelsiran sodium can be used for research on early-onset Alzheimer's disease .
Art. -Nr.: HY-50882A
CAS. Nr.: 851599-82-1
Target:
Forschungsgebiete:
ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .
Art. -Nr.: HY-147674
CAS. Nr.: 2494195-61-6
Target:
Forschungsgebiete:
Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 114 nM .
Art. -Nr.: HY-P4553
CAS. Nr.: 59227-86-0
Target:
Forschungsgebiete:
Art. -Nr.: HY-P4553A
Target:
Forschungsgebiete:
Art. -Nr.: HY-149396A
CAS. Nr.: 3052551-20-6
Target:
Forschungsgebiete:
FXIIa-IN-1 hydrochloride is the hydrochloride of FXIIa-IN-1 (HY-149396). FXIIa-IN-1 (Compound 22) is a Factor XIIa inhibitor (Ki app: 97.8 nM). FXIIa-IN-1 can be used for research of thrombosis .
Art. -Nr.: HY-P4926
CAS. Nr.: 1802078-33-6
Target:
Forschungsgebiete:
Art. -Nr.: HY-13769
CAS. Nr.: 769856-81-7
Synonyms: TPU260
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
TPT-260 (TPU260), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
Art. -Nr.: HY-P10487
Target:
Forschungsgebiete:
Art. -Nr.: HY-118245
CAS. Nr.: 1185282-03-4
Target:
APP-FUBINACA is a cannabinoid receptor agonist and a derivative of phenylalaninamide-based indazole-3-carboxamide. APP-FUBINACA exhibits neurostimulatory effects .
Art. -Nr.: HY-128090
CAS. Nr.: 160470-73-5
Target:
Forschungsgebiete:
Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection .
Art. -Nr.: HY-RS00864
Target:
Forschungsgebiete:
App Mouse Pre-designed siRNA Set A contains three designed siRNAs for App gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS00865
Target:
Forschungsgebiete:
App Rat Pre-designed siRNA Set A contains three designed siRNAs for App gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P10180
CAS. Nr.: 148914-01-6
Synonyms: APP (319-335)
Target:
Forschungsgebiete:
Art. -Nr.: HY-147672
CAS. Nr.: 2502167-19-1
Target:
Forschungsgebiete:
IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 88 nM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
