160470-73-5
160470-73-5
Chemical Structure
Apstatin
- CAS No.: 160470-73-5
- Formula:C23H33N5O5
- Molecular Weight:459.54
IUPAC Name: (S)-N-((S)-1-amino-1-oxopropan-2-yl)-1-(((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-prolyl)pyrrolidine-2-carboxamide
InChIKey: YVUUZAPYLPWFHE-HXFGRODQSA-N
SMILES: C[C@@H](C(N)=O)NC([C@H]1N(C([C@H]2N(C([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)CCC2)=O)CCC1)=O
Biological Activity: Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection[1][2].
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Apstatin | Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection. | |||||||||||||||||||||
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References
- [1]. Wolfrum S, et al. Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway. Br J Pharmacol. 2001 Sep;134(2):370-4. [Content Brief]
- [2]. Maggiora LL, et al. Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem. 1999 Jul 1;42(13):2394-402. [Content Brief]
Keywords
