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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
azide functional groups
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "azide functional groups" in MCE Product Catalog:
Cat. No.: HY-137073
CAS No.: 1998119-13-3
Cat. No.: HY-W1051916C
Cat. No.: HY-W1051916
Cat. No.: HY-W1051916A
Cat. No.: HY-W1051916B
Cat. No.: HY-W1051916D
Cat. No.: HY-W1051916H
Cat. No.: HY-W1051916I
Cat. No.: HY-P11886
Synonyms: GNYTCEVTELTREGETIIELK-azide
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Cat. No.: HY-L256
100 compounds
In modern drug discovery and chemical biology research, the azide group (-N3) is an important functional moiety that is widely used in click chemistry, biomolecular labeling, drug delivery systems, and prodrug design due to its unique reactivity and bioorthogonality.
The MCE Azide Structural Compound Library contains 100 compounds featuring -N3 functional groups. It is designed for the construction of click chemistry reaction systems and the subsequent development of functional molecules. This library enables the rapid assembly of targeting ligands, linkers, and functional molecular modules, thereby accelerating PROTAC assembly, optimization of antibody-drug conjugate (ADC) linkers, and the development of biological labeling probes. In addition, the high reaction selectivity and excellent biocompatibility of the azide group allow it to maintain stable reactivity even in complex biological environments, improving controllability and efficiency in drug design. It serves as an indispensable molecular tool in modern medicinal chemistry and chemical biology research.
Cat. No.: HY-D3574
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AF488 Picolyl Azide is a Fluorescent dye designed for bioorthogonal visualization applications. AF488 Picolyl Azide functions via copper (I)-catalyzed azide-alkyne cycloaddition click chemistry, where its azide group undergoes covalent reaction with alkyne-functionalized molecules to form fluorescent triazole conjugates. AF488 Picolyl Azide enables the visualization of metabolically labeled isoprenoids in bacteria, which localize to the cell membrane and division septum .
Cat. No.: HY-183022
CAS No.: 896465-45-5
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1-(3-Azidopropyl)-1H-pyrrole-2,5-dione is a maleimide derivative with a 3-azidopropyl substituent, used to introduce an azide functional group to bovine serum albumin (BSA). 1-(3-Azidopropyl)-1H-pyrrole-2,5-dione reacts with the free, solvent-accessible thiol group of BSA to produce azide-functionalized BSA, which is used in click chemistry to form a TLL-BSA hetero-dimer .
Cat. No.: HY-D3581
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AF594 Picolyl Azide is a composite fluorescent probe formed by covalent linkage of the Alexa Fluor 594 fluorophore and the Picolyl Azide functional group via chemical bonds. AF594 Picolyl Azide contains a copper chelation domain, and through the copper-catalyzed azide-alkyne cycloaddition click chemistry reaction, it can covalently label alkyne-bearing target molecules and generate fluorescent detection signals. AF594 Picolyl Azide can be used for the detection of alkyne-modified sialylated glycoconjugates, and can also label nascent bacterial polypeptides to determine bacterial protein synthesis rates .
Cat. No.: HY-174359
Cat. No.: HY-174359B
Cat. No.: HY-174359D
Cat. No.: HY-174359E
Cat. No.: HY-L258
437 compounds
In modern medicinal chemistry and chemical biology research, alkyne (-C≡C-) structures play an important role in click chemistry, bioorthogonal labeling, and the construction of functional molecules due to their unique linear geometry and high reactivity. In particular, driven by the development of copper-catalyzed azide-alkyne cycloaddition (CuAAC) and copper-free click reactions (SPAAC), terminal alkyne groups have become important “chemical handles” for building complex biomolecular systems.
The MCE Alkyne Compound Library contains 437 compounds designed for the construction of click chemistry reaction systems and the development of diverse functional molecules. In drug discovery, these structures serve as key reactive sites that can efficiently undergo click reactions with azide groups, enabling modular assembly of PROTAC molecules, construction of ADC linkers, and rapid synthesis of bioorthogonal labeling probes. In addition, alkyne groups exhibit high stability, mild reaction conditions, and excellent biocompatibility, allowing them to maintain reactivity in complex biological environments. This contributes to improved efficiency and controllability in drug development, making them indispensable chemical building blocks in modern drug design and functional molecular engineering.
Cat. No.: HY-185901
Cat. No.: HY-183038
CAS No.: 1356409-07-8
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2-Phenyl-1-octen-7-yn-1-one is an alkyne-functionalized enone with site-selective reactivity toward the N-terminal α-amino group of peptides and proteins. 2-Phenyl-1-octen-7-yn-1-one can undergo click chemistry with azides via its alkyne moiety to enable further protein functionalization. 2-Phenyl-1-octen-7-yn-1-one modifies unprotected peptide libraries as well as proteins including insulin, lysozyme, RNaseA and BCArg .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
