206 Results for "

second-generation

" in MedChemExpress (MCE) Product Catalog:
Products (206)

206 Results for "second-generation" in MCE Product Catalog:

Cat. No.: HY-B1166
CAS No.: 42540-40-9
Synonyms: Cefamandole formate sodium
Target:  

Bacterial Antibiotic

Research Areas:  

Infection Inflammation/Immunology

Cefamandole nafate (Cefamandole formate sodium) is a second-generation broad-spectrum cephalosporin antibiotic .
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Cat. No.: HY-132579
CAS No.: 1709886-74-7
Purity:  94.13%
Synonyms: RG6042; IONIS-HTTRx
Target:  

Huntingtin

Research Areas:  

Neurological Disease

Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .
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Cat. No.: HY-13301
CAS No.: 958025-66-6
Target:  

HSP

Research Areas:  

Cancer

MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity .
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Cat. No.: HY-U00116
CAS No.: 142344-87-4
Target:  

Adenosine Receptor

Research Areas:  

Cardiovascular Disease

GP531 is a potent, second-generation adenosine regulating agent, is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.
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Cat. No.: HY-112359
CAS No.: 1422253-37-9
Target:  

β-catenin Wnt

Research Areas:  

Cancer

C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300 .
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Cat. No.: HY-132579A
Purity:  97.36%
Synonyms: RG6042 sodium; IONIS-HTTRx sodium
Target:  

Huntingtin

Research Areas:  

Neurological Disease

Tominersen sodium is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) .
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Cat. No.: HY-139419
CAS No.: 1194396-71-8
Purity:  98.34%
Synonyms: NCX 470
Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma .
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Cat. No.: HY-B1682A
CAS No.: 121961-22-6
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Loracarbef hydrate, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class .
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Cat. No.: HY-164419A
CAS No.: 1826859-79-3
Synonyms: COR-004 sodium; ATL1103 sodium; ISIS 227452 sodium
Target:  

GHR

Research Areas:  

Others

Atesidorsen sodium is a second-generation, antisense oligomer designed to inhibit translation of human growth hormone receptor (GHR) mRNA
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Cat. No.: HY-163127
Target:  

AUTACs Autophagy

Research Areas:  

Cancer

AUTAC2-2G is a second-generation AUTAC with a 100-fold increase in activity .
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Cat. No.: HY-18636
CAS No.: 1204975-42-7
Synonyms: NVP-LEQ506
Target:  

Smo

Research Areas:  

Cancer

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
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Cat. No.: HY-13542
CAS No.: 929901-49-5
Synonyms: SGI-110
Target:  

DNA Methyltransferase

Research Areas:  

Cancer

Guadecitabine (SGI-110) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) .
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Cat. No.: HY-B0458A
CAS No.: 92665-29-7
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Cefprozil is a second-generation cephalosporin type antibiotic. Cefprozil exhibits broad-spectrum antibacterial activity, and is orally active. Cefprozil can be used for the study of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections .
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Cat. No.: HY-17042S1
CAS No.: 774596-22-4
Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
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Cat. No.: HY-16309
CAS No.: 882757-24-6
Target:  

Phosphatase

Research Areas:  

Metabolic Disease

MB-07803 is an orally active second-generation prodrug inhibitor of fructose-1,6-bisphosphatase (FBP1). MB-07803 directly inhibits the rate-limiting enzyme in gluconeogenesis. MB-07803 regulates blood glucose and is used in studies of type 2 diabetes .
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Cat. No.: HY-B1682
CAS No.: 76470-66-1
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Loracarbef, a cephalosporin antibiotic, is an orally active second-generation synthetic beta-lactam antibiotic of the carbacephem class .
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Cat. No.: HY-13675
CAS No.: 852536-39-1
Purity:  99.01%
Synonyms: NV-143
Target:  

Wnt

ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .
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Cat. No.: HY-B1256S
CAS No.: 1803240-98-3
Cefuroxime-d3 is deuterium labeled Cefuroxime (sodium). Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
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Cat. No.: HY-145559
CAS No.: 1450642-92-8
Synonyms: KU-596
Target:  

HSP

Research Areas:  

Metabolic Disease

Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response .
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Cat. No.: HY-153481
CAS No.: 350263-41-1
Synonyms: ISIS-107248; Avicursen
Target:  

Integrin

Research Areas:  

Others

ATL 1102 (Avicursen) is a novel second-generation antisense oligonucleotide to CD49d mRNA
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