1709886-74-7
1709886-74-7
Chemical Structure
Tominersen
Synonym(s): RG6042; IONIS-HTTRx
- CAS No.: 1709886-74-7
- Formula:N/A
- Molecular Weight:7078.00
SMILES: [Tominersen]
Biological Activity: Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD)[1][2].
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Tominersen | 96.32% | Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD). | ||||||||||||||||||||
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References
- [1]. Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington's Disease. N Engl J Med. 2019 Jun 13;380(24):2307-2316. [Content Brief]
- [2]. Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74(6):1031-44. [Content Brief]
Keywords
