774596-22-4
Chemical Structure
Cetirizine-d8
- CAS No.: 774596-22-4
- Formula:C21H17D8ClN2O3
- Molecular Weight:396.94
IUPAC Name: 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethoxy)acetic acid
InChIKey: ZKLPARSLTMPFCP-BGKXKQMNSA-N
SMILES: O=C(O)COCCN1C([2H])([2H])C([2H])([2H])N(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)C([2H])([2H])C1([2H])[2H]
Biological Activity: Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
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Cetirizine-d8 | 96.46% | Cetirizine-d8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response. | ||||||||||||||||||||
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Cetirizine (Standard) | ≥98% | Cetirizine (Standard) is the analytical standard of Cetirizine. This product is intended for research and analytical applications. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response. | ||||||||||||||||||||
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Cetirizine | 99.79% | Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response. | ||||||||||||||||||||
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- [1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.
- [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [Content Brief]
- [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. [Content Brief]
