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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
104 Results for "
PKB
" in MedChemExpress (MCE) Product Catalog:
Products (104)
104 Results for "PKB" in MCE Product Catalog:
Cat. No.: HY-P705727
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKT1; Protein Kinase B; AKT Serine/Threonine Kinase 1; PKB Alpha; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1 Isoform 2; PKB; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase; Non-Specific Serine/Th
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P85561
Synonyms: AKT 1; AKT; AKT1; AKT1_HUMAN; C AKT; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC; RAC PK Alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; vAKT Murine Thymoma Viral Oncogene Homolog 1
Cat. No.: HY-P12209
CAS No.: 312773-04-9
Research Areas:
CKRPRAASFAE is a glycogen synthase kinase 3-β-derived PKB/Akt peptide substrate that is used for in vitro kinase activity assays .
Cat. No.: HY-108458R
CAS No.: 459429-39-1
Target:
Research Areas:
SB 452533 (Standard) is the analytical standard of SB 452533 (HY-108458). This product is intended for research and analytical applications. SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8 .
Cat. No.: HY-107834R
CAS No.: 372196-67-3
Target:
Research Areas:
PIK-75 (Standard) is the analytical standard of PIK-75 (HY-107834). This product is intended for research and analytical applications. PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM) . PIK-75 induces apoptosis .
Cat. No.: HY-10895AR
CAS No.: 792173-99-0
Synonyms: SB334867A free base (Standard)
Research Areas:
SB-334867 free base (Standard) is the analytical standard of SB-334867 (free base) (HY-10895A). This product is intended for research and analytical applications. SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively . SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo .
Cat. No.: HY-P701738
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDPK1; PKB Kinase Like Gene 1; 3-Phosphoinositide Dependent Protein Kinase 1; PKB Kinase; PDK1; PRO0461; 3-Phosphoinositide-Dependent Protein Kinase 1; HPDK1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701739
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDPK1; PKB Kinase Like Gene 1; 3-Phosphoinositide Dependent Protein Kinase 1; PKB Kinase; PDK1; PRO0461; 3-Phosphoinositide-Dependent Protein Kinase 1; HPDK1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-100395R
CAS No.: 36098-33-6
Target:
Reference Standards Mitochondrial Metabolism Reactive Oxygen Species (ROS) Akt p38 MAPK Bcl-2 Family Apoptosis
Research Areas:
F16 (Standard) is the analytical standard of F16 (HY-100395). This product is intended for research and analytical applications. F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
Cat. No.: HY-103112BR
CAS No.: 200940-22-3
Target:
Research Areas:
SB 243213 (Standard) is the analytical standard of SB 243213 (HY-103112B). This product is intended for research and analytical applications. SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders .
Cat. No.: HY-182635
CAS No.: 83812-65-1
Research Areas:
ICI 147798 is an orally effective β-adrenoceptor antagonist with a pKB of 9.1 (in guinea pig right atrium) and 8.8 (in guinea pig trachea). ICI 147798 acts as a diuretic and intraocular pressure-lowering agent. ICI 147798 blocks β-adrenoceptors, inhibits isoproterenol-induced tachycardia and vasodepressor responses, exhibits slowly dissociating, insurmountable antagonism against β1-adrenoceptors, and shows surmountable competitive antagonism against β2-adrenoceptors. ICI 147798 induces natriuresis and kaliuresis, inhibits sodium transport, and reduces intraocular pressure .
Cat. No.: HY-P75519
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKT3; V-Akt Murine Thymoma Viral Oncogene Homolog 3; AKT Serine/Threonine Kinase 3; Non-Specific Serine/Threonine Protein Kinase; PKBG; RAC-Gamma Serine/Threonine Protein Kinase; RAC-Gamma; Protein Kinase B, Gamma; PRKBG; Protein Kinase B Gamma; RAC-Gamma Serine/Threonine-Protein Kinase; Protein Kinase Akt-3; RAC-PK-Gamma; PKB-GAMMA; PKB Gamma; MPPH2; STK-2; MPPH; V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706018
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: AKT3; V-Akt Murine Thymoma Viral Oncogene Homolog 3; AKT Serine/Threonine Kinase 3; Non-Specific Serine/Threonine Protein Kinase; PKBG; RAC-Gamma Serine/Threonine Protein Kinase; RAC-Gamma; Protein Kinase B, Gamma; PRKBG; Protein Kinase B Gamma; RAC-Gamma Serine/Threonine-Protein Kinase; Protein Kinase Akt-3; RAC-PK-Gamma; PKB-GAMMA; PKB Gamma; MPPH2; STK-2; MPPH; V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705867
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PTK2B; Protein-Tyrosine Kinase 2-Beta; Prev. FAK2; Cell Adhesion Kinase Beta; RAFTK; Focal Adhesion Kinase 2; CADTK; CAK-Beta; CAKB; FADK 2; PYK2; PTK2B Protein Tyrosine Kinase 2 Beta; PTK; Protein Kinase B; Calcium-Regulated Non-Receptor Proline-Rich Tyr
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705866
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PTK2B; Protein-Tyrosine Kinase 2-Beta; Prev. FAK2; Cell Adhesion Kinase Beta; RAFTK; Focal Adhesion Kinase 2; CADTK; CAK-Beta; CAKB; FADK 2; PYK2; PTK2B Protein Tyrosine Kinase 2 Beta; PTK; Protein Kinase B; Calcium-Regulated Non-Receptor Proline-Rich Tyr
Species:
Human
Source:
sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
