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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
130 Results for "
cardiac function
" in MedChemExpress (MCE) Product Catalog:
Products (130)
130 Results for "cardiac function" in MCE Product Catalog:
Cat. No.: HY-B0124R
CAS No.: 68291-97-4
Synonyms: AD 810 (Standard); CI 912 (Standard)
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Zonisamide (Standard) is the analytical standard of Zonisamide. This product is intended for research and analytical applications. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
Cat. No.: HY-B0124S2
Synonyms: AD 810-13C6; CI 912-13C6
Cat. No.: HY-N6020BR
CAS No.: 21913-99-5
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Cat. No.: HY-P5319
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Cat. No.: HY-106987
CAS No.: 139146-65-9
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SP/W-5186 is a nitric oxide (NO) donor agent containing a cysteine structure. SP/W-5186 can improve cardiac function, reduce myocardial damage, protect vascular endothelial function and inhibit inflammation and oxidative stress. SP/W-5186 has the ability to inhibit oxidative damage induced by peroxynitrite (ONOO⁻). SP/W-5186 can be used in the research of myocardial ischemia-reperfusion injury .
Cat. No.: HY-D0711S2
CAS No.: 2861905-57-7
Synonyms: Foxgreen-d7; IC Green-d7; Cardiogreen-d7
Cat. No.: HY-19216
CAS No.: 172489-10-0
Synonyms: SKP 450
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KR-30450 (SKP 450) is a potent K +ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255). KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release .
Cat. No.: HY-101390B
CAS No.: 102993-22-6
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Niguldipine is a calcium channel blocker with activity in regulating cardiovascular function. Niguldipine can reduce systolic and diastolic blood pressure, thereby increasing heart rate and cardiac output. Niguldipine exhibits dose-dependent and sustained increases in coronary blood flow. Niguldipine also increases perfusion in the kidneys and femoral arteries, but the effect is temporary and to a lesser extent. The effect of Niguldipine on myocardial metabolism is not significant .
Cat. No.: HY-B0252S2
CAS No.: 1261396-79-5
Synonyms: HCTZ-13C6
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Cat. No.: HY-145284
CAS No.: 2762567-70-2
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APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease .
Cat. No.: HY-109128R
CAS No.: 1970972-74-7
Synonyms: MYK-491 (Standard)
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Danicamtiv (Standard) is the analytical standard of Danicamtiv (HY-109128). This product is intended for research and analytical applications. Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .
Cat. No.: HY-183138
CAS No.: 86408-45-9
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N-Demethyldiltiazem is a metabolite of Diltiazem (HY-B0632). N-Demethyldiltiazem increases coronary blood flow, modulates cardiac function, decreases systemic blood pressure and heart rate, and alters papillary muscle developed tension .
Cat. No.: HY-106486A
CAS No.: 62134-34-3
Butoprozine hydrochloride functions as a cardiac depressant agent.
Cat. No.: HY-12502C
CAS No.: 128194-13-8
Synonyms: (R)-NZ-105; (-)-Efonidipine
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(R)-Efonidipine ((R)-NZ-105) is an orally active, selective T-type Ca 2+ channel blocker. (R)-Efonidipine does not inhibit high-voltage-activated Ca 2+ channels, voltage-dependent Na + channels, or Ca 2+-activated K + channels. (R)-Efonidipine modulates cardiac autonomic function by increasing parasympathetic activity and decreasing sympathetic activity. (R)-Efonidipine significantly improves survival in a mouse model of dilated cardiomyopathy. (R)-Efonidipine can be used in research on ischemic encephalopathy, heart failure, and hypertension .
Cat. No.: HY-FLB1409
CAS No.: 87-33-2
Synonyms: ISDN solution
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Isosorbide dinitrate solution is mainly composed of Isosorbide dinitrate (HY-B1409). Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) .
Cat. No.: HY-E70854
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PKCε is an isoform of the large PKC family of protein kinases. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε Recombinant Human Active Protein Kinase is a recombinant PKCε protein that can be used to study PKCε-related functions .
Cat. No.: HY-P12125
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Cat. No.: HY-111475R
CAS No.: 219315-22-7
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Mitochondrial fusion promoter M1 (Standard) is the analytical standard of Mitochondrial fusion promoter M1 (HY-111475). This product is intended for research and analytical applications. Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury .
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Erythrityl tetranitrate (Tetranitrate; Nitroerythrite), a nitrate ester, is a long-acting vasodilator with properties similar to nitroglycerin. Erythrityl tetranitrate decreases the counter load of the heart and improvement of the pump function of left ventricle in an acute experiment in case of chronic cardiac insufficiency with stasis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
