86408-45-9
86408-45-9
Chemical Structure
N-Demethyldiltiazem
- CAS No.: 86408-45-9
- Formula:C21H24N2O4S
- Molecular Weight:400.49
InChIKey: YOMLDISQSWWYOT-UXHICEINSA-N
SMILES: CC(O[C@@H]1[C@H](C2=CC=C(C=C2)OC)SC3=CC=CC=C3N(C1=O)CCNC)=O
Biological Activity: N-Demethyldiltiazem is a metabolite of Diltiazem (HY-B0632). N-Demethyldiltiazem increases coronary blood flow, modulates cardiac function, decreases systemic blood pressure and heart rate, and alters papillary muscle developed tension[1][2].
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N-Demethyldiltiazem | N-Demethyldiltiazem is a metabolite of Diltiazem (HY-B0632). N-Demethyldiltiazem increases coronary blood flow, modulates cardiac function, decreases systemic blood pressure and heart rate, and alters papillary muscle developed tension. | |||||||||||||||||||||
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N-Desmethyl diltiazem-d4 | N-Desmethyl diltiazem-d4 is deuterium labeled N-Desmethyl diltiazem. | |||||||||||||||||||||
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References
- [1]. Yabana H, et al. Cardiovascular effects of the metabolites of diltiazem in dogs. J Cardiovasc Pharmacol. 1985;7(1):152-157. [Content Brief]
- [2]. Boyd R A, et al. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose[J]. Clinical Pharmacology & Therapeutics, 1989, 46(4): 408-419. [Content Brief]
