N-Demethyldiltiazem
N-Demethyldiltiazem is a metabolite of Diltiazem (HY-B0632). N-Demethyldiltiazem increases coronary blood flow, modulates cardiac function, decreases systemic blood pressure and heart rate, and alters papillary muscle developed tension.
For research use only. We do not sell to patients.
- CAS No.: 86408-45-9
- Formula: C21H24N2O4S
- Molecular Weight:400.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
N-Demethyldiltiazem (1.5-1500 μg; i.a.; single dose or 1 μg/min; continuous infusion; 20 minutes) produces dose-dependent coronary vasodilation with minimal negative inotropic effects in blood-perfused canine papillary muscles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Mongrel dogs (male, 12-22 kg, anesthetized, open-chest preparation)[1]
-
Dosage:15, 50, 150, 500 μg/kg
-
Administration:i.v.; single dose
-
Result:Increased coronary blood flow and left ventricular dP/dt_max, and decreased blood pressure, left ventricular pressure, and heart rate, with effects lasting ~10 minutes.
Exhibited a relative potency of 1/5 for inducing a 50% increase in coronary blood flow, and 1/3 for inducing a 10% decrease in mean blood pressure, relative to Diltiazem (potency 1).
Caused a <10% decrease in mean blood pressure at doses that increased coronary blood flow by 50%.
Chemical Information
-
CAS No. 86408-45-9
-
Molecular Weight 400.49
-
Formula C21H24N2O4S
-
SMILES
CC(O[C@@H]1[C@H](C2=CC=C(C=C2)OC)SC3=CC=CC=C3N(C1=O)CCNC)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yabana H, et al. Cardiovascular effects of the metabolites of diltiazem in dogs. J Cardiovasc Pharmacol. 1985;7(1):152-157. [Content Brief]
[2]. Boyd R A, et al. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose[J]. Clinical Pharmacology & Therapeutics, 1989, 46(4): 408-419. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Demethyldiltiazem Related Classifications
HY-183138 Related Classifications
Powered by Bioz