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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
115 Results for "
pp2
" in MedChemExpress (MCE) Product Catalog:
Products (115)
115 Results for "pp2" in MCE Product Catalog:
Cat. No.: HY-P85517
Synonyms: pp2A beta; pp2A-beta; pp2AB_HUMAN; pp2Abeta; pp2CB; ppp2cb; Protein phosphatase 2; formerly 2A; , catalytic subunit, beta isoform; Protein phosphatase 2 catalytic subunit beta isozyme; Protein phosphatase 2, catalytic subunit, beta isoform; Protein phosphatase 2A catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Serine/threonine protein phosphatase 2A catalytic subunit beta; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform.
Cat. No.: HY-P87987
Synonyms: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, pp2A B subunit isoform B'-delta, pp2A B subunit isoform B56-delta, pp2A B subunit isoform PR61-delta, pp2A B subunit isoform R5-delta, ppP2R5D
Cat. No.: HY-P810909
Synonyms: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, pp2A B subunit isoform B'-alpha, pp2A B subunit isoform B56-alpha, pp2A B subunit isoform PR61-alpha, pp2A B subunit isoform R5-alpha, PR61alpha, ppP2R5A
Cat. No.: HY-P811673
Synonyms: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, pp2A subunit B isoform B55-alpha, pp2A subunit B isoform PR55-alpha, pp2A subunit B isoform R2-alpha, pp2A subunit B isoform alpha, ppP2R2A
Cat. No.: HY-184894
Target:
Research Areas:
RK-1205-I is a protein phosphatase 2A (PP2A) inhibitor and fungal growth inhibitor. RK-1205-I inhibits PP2A activity in fungal cells, leading to the accumulation of Ser/Thr phosphorylated proteins. RK-1205-I acts as a morphoregulator and induces unique morphological changes in filamentous fungi. RK-1205-I inhibits the growth of various fungi, including Aspergillus oryzae, Aspergillus fumigatus and Candida auris. RK-1205-I can be used for the research of fungal infections .
Cat. No.: HY-L081
185 compounds
Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.
Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.
MCE supplies a unique collection of 185 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.
Cat. No.: HY-P703005
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ppM1F; Protein Phosphatase 1F (pp2C Domain Containing); Protein Phosphatase, Mg2+/Mn2+ Dependent 1F; CaM-Kinase Phosphatase; Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase; Protein Fem-2 Homolog; CaMKPase; Protein Phosphatase 1F (pp2C Domain Conta
Species:
Human
Source:
E. coli
Cat. No.: HY-P705907
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: ppP2CA; RP-C; Protein Phosphatase 2 Catalytic Subunit Alpha; Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform; pp2Calpha; Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform; pp2AC; Serine/Threonine-Protein Phosphatase; Serine/Thr
Species:
Human
Source:
E. coli
Cat. No.: HY-P701180
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ppM1H; Protein Phosphatase 1H (pp2C Domain Containing); Prev. ARHCL1; Protein Phosphatase 1H; KIAA1157; FLJ13253; NERpp-2C; URCC2; Neurite Extension-Related Protein Phosphatase Related To pp2C; Protein Phosphatase, Mg2+/Mn2+ Dependent, 1H; Protein Phospha
Species:
Human
Source:
HEK293
Cat. No.: HY-P702895
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ppP2CA; RP-C; Protein Phosphatase 2 Catalytic Subunit Alpha; Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform; pp2Calpha; Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform; pp2AC; Serine/Threonine-Protein Phosphatase; Serine/Thr
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-185310A
Target:
Research Areas:
MKI-2 hydrochloride is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 hydrochloride induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 hydrochloride reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 hydrochloride inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 hydrochloride inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 hydrochloride can be used for the research of cancer, such as breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
